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Phase 1 Study of ABI-009 (nab-rapamycin) in Pediatric Patients with Recurrent or Refractory Solid Tumors, including CNS Tumors as a Single Agent and in Combination with Temozolomide and Irinotecan

Clinical Trial Protocol # ADVL1514 | Adolescents and Young Adults, Recurrent/Refractory Cancer, Solid Tumors | Contact (714) 509-8646

https://www.choc.org/clinical-trials/a-phase-1-study-of-abi-009-nab-rapamycin-in-pediatric-patients-with-recurrent-or-refractory-solid-tumors-including-cns-tumors-as-a-single-agent-and-in-combination-with-temozolomide-and-irinotecan/

Phase 1/2 Study of Lenvatinib in Combination with Everolimus in Recurrent and Refractory Pediatric Solid Tumors, including CNS

Clinical Trial Protocol # ADVL1711 | Adolescents and Young Adults, Recurrent/Refractory Cancer, Solid Tumors | Contact (714) 509-8646

https://www.choc.org/clinical-trials/a-phase-12-study-of-lenvatinib-in-combination-with-everolimus-in-recurrent-and-refractory-pediatric-solid-tumors-including-cns/

Phase II open-label global study to evaluate the effect of dabrafenib in combination with trametinib in children and adolescent patients with BRAF V600 mutation positive relapsed or refractory High Grade Glioma (HGG)

Clinical Trial Protocol # CDRB436G2201 | Adolescents and Young Adults, Brain Tumor/Central Nervous System/Neuro-Oncology, Recurrent/Refractory Cancer, Solid Tumors | Contact (714) 509-8646

https://www.choc.org/clinical-trials/phase-ii-open-label-global-study-to-evaluate-the-effect-of-dabrafenib-in-combination-with-trametinib-in-children-and-adolescent-patients-with-braf-v600-mutation-positive-relapsed-or-refractory-high-gr/

Yun, Christine S., NP

Christine Yun is a nurse practitioner who specializes in oncology. She provides care for pediatric cancer patients at CHOC in Orange County.

https://www.choc.org/providers/oncology/christine-s-yun-np/

No Place Like CHOC: Jenee Areeckal

There's no place like CHOC. Jenee Areeckal, Oncology Social Worker at CHOC Hospital, tells us about the importance of treating the whole family.

https://www.choc.org/video/place-like-choc-jenee-areeckal/

Adolescent and Young Adult (AYA) Treatment Program

CHOC has one of the only cancer programs in the country just for teens and young adults, meaning we “get” what they need—medically, emotionally and beyond.

https://www.choc.org/cancer/adolescent-young-adult-treatment-program/

Side Effects of Chemotherapy and Radiation in Children

While chemotherapy and radiation are both treatments used to treat cancer, they differ in the way they work.

https://www.choc.org/health-topics/side-effects-of-chemotherapy-and-radiation-in-children/

Parent Advice Line

To use PAL, simply call (714) 912-8927, enter the four-digit topic numbers listed on this web page, or stay on the line for a complete listing of topics.

https://www.choc.org/programs-services/parent-advice-line/

Sender, Leonard S. MD

Dr. Sender is a pediatric oncologist who treats children and teens at CHOC.

https://www.choc.org/providers/oncology/leonard-sender-md/

Lin, Carol MD

Dr. Lin is a CHOC Specialist in pediatric hematology/oncology and is board certified in pediatrics.

https://www.choc.org/providers/oncology/carol-lin-md/

Oncology Clinical Trial: Study of Kidney Tumors in Younger Patients

Clinical Trial Protocol # AREN03B2 | Biology/Genomics, Registry | Contact (714) 509-8646

https://www.choc.org/clinical-trials/oncology-clinical-trials/study-of-kidney-tumors-in-younger-patients/

Kirov, Ivan I. MD

Dr. Kirov serves as CHOC Specialists director of the lymphoma program and recurrent/refractory cancer program.

https://www.choc.org/providers/oncology/ivan-kirov-md/

Huynh, Van T. MD

Dr. Huynh is a pediatric oncologist who specializes in acute leukemia. She is board certified in both general pediatrics and pediatric hematology/oncology.

https://www.choc.org/providers/oncology/van-huynh-md/

Morales, Sonia MD

Dr. Sonia Morales is a board certified pediatric oncologist at CHOC Hospital in Orange County.

https://www.choc.org/providers/oncology/sonia-morales-md/

Rubin, Elyssa MD

Dr. Rubin serves as the director of the Bone and Soft Tissue Tumor Program at CHOC Hospital and is an oncologist with CHOC Specialists.

https://www.choc.org/providers/oncology/elyssa-rubin-md/

Mucci, Grace PhD

Dr. Grace Mucci, PhD, is a board-certified pediatric neuropsychologist and coordinator of the Neuropsychology Program at CHOC Hospital.

https://www.choc.org/providers/psychology/grace-mucci-phd/

Navalkele, Pournima D. MD

Dr. Pournima Navalkele is a board certified pediatric oncologist at CHOC Hospital in Orange County.

https://www.choc.org/providers/oncology/pournima-navalkele-md/

ADVL1615, A Phase 1 Study of Pevonedistat (MLN4924, IND# 136078), a NEDD8 Activating Enzyme (NAE) Inhibitor, in Combination with Temozolomide and Irinotecan in Pediatric Patients with Recurrent or Refractory Solid Tumors

Clinical Trial Protocol # ADVL1615 | Adolescents and Young Adults, Brain Tumor/Central Nervous System/Neuro-Oncology, Recurrent/Refractory Cancer, Solid Tumors | Contact (714) 509-8646

https://www.choc.org/clinical-trials/advl1615-a-phase-1-study-of-pevonedistat-mln4924-ind-136078-a-nedd8-activating-enzyme-nae-inhibitor-in-combination-with-temozolomide-and-irinotecan-in-pediatric-patients-with-recurrent-or-ref/

Horvath, Agnes MD

Dr. Horvath is a pediatric hematology/oncology with CHOC Specialists and is board certified in pediatrics, pediatric hematology/oncology.

https://www.choc.org/providers/oncology/agnes-horvath-md/

Neudorf, Steven M. MD

Dr. Neudorf is a CHOC Specialist in pediatric oncology at CHOC Hospital.

https://www.choc.org/providers/oncology/steven-neudorf-md/

Histiocytosis: Dr. Torno

Dr. Lilibeth Torno, Clinical Director of Hyundai Cancer Institute at CHOC, describes symptoms and treatment of histiocytosis.

https://www.choc.org/video/histiocytosis-dr-torno/

Clinical Trials: Dr. Sender

Dr. Leonard Sender, Medical Director, Hyundai Cancer Institute at CHOC, describes for us the three phases of clinical trials.

https://www.choc.org/video/clinical-trials-dr-sender/

Oncology Clinical Trial: A Phase II Study of Dasatinib Therapy in Children and Adolescents with Newly Diagnosed Chronic Phase CML or with Ph+ Leukemias Resistant or Intolerant to Imatinib

Clinical Trial Protocol # 90325 | Adolescents and Young Adults, Leukemia/Lymphoma, Recurrent/Refractory Cancer, oncology | Contact (714) 509-8646

https://www.choc.org/clinical-trials/oncology-clinical-trials/phase-ii-study-dasatinib-theraphy-children-adolescents-chronic-phase-cml-ph-leukemias-resistant-intolerant-imatinib/

Oncology Clinical Trial: Vincristine Sulfate Liposome Injection (Marqibo®) in Combination With UK ALL R3 Induction Chemotherapy for Children, Adolescents, and Young Adults With Relapsed ALL

Clinical Trial Protocol #T2012-002 | Adolescents and Young Adults, Leukemia/Lymphoma, Recurrent/Refractory Cancer | Contact (714) 509-8646

https://www.choc.org/clinical-trials/oncology-clinical-trials/vincristine-sulfate-liposome-injection-marqibo-in-combination-with-uk-all-r3-induction-chemotherapy-for-children-adolescents-and-young-adults-with-relapsed-all/

Phase 2 Trial of XL184 (Cabozantinib) an Oral Small-Molecule Inhibitor of Multiple Kinases, in Children and Young Adults with Refractory Sarcomas, Wilms Tumor, and Other Rare Tumors

Clinical Trial Protocol # ADVL1622 | Adolescents and Young Adults, Recurrent/Refractory Cancer, Solid Tumors | Contact (714) 509-8646

https://www.choc.org/clinical-trials/phase-2-trial-of-xl184-cabozantinib-an-oral-small-molecule-inhibitor-of-multiple-kinases-in-children-and-young-adults-with-refractory-sarcomas-wilms-tumor-and-other-rare-tumors/