Gender, Puberty and Sex Development Program

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The CHOC Gender, Puberty and Sex Development (GPS) Program offers comprehensive medical, psychological and support services to children and teens with non-conforming gender expression, genetic variations in the X and Y chromosomes, and those with differences in genital development.

Led by board-certified, fellowship-trained pediatric endocrinologists, CHOC GPS Program is a multidisciplinary program that offers a comprehensive team approach to ensure your child receives the highest quality of care.

What We Treat

As one of the top-ranked children’s hospitals in the nation for endocrinology by U.S. News & World Report, we are committed to providing the highest quality of care for kids of all ages with gender, puberty and sexual differentiation issues. Our experienced medical providers are familiar with the physical, mental and emotional aspects of each unique condition.

  • Turner Syndrome
  • Klinefelter Syndrome
  • Transgender / Non-conforming children
  • Genital Ambiguity / Differences in Sex Development
  • Congenital Adrenal Hyperplasia

US News and World Report Best Children's Hospitals Diabetes & Endocrinology

Gender, Puberty and Sex Development Services

teenage boy smiling with father

At CHOC, we help navigate the complex pathways to gender, puberty and sex development in the medical and mental health systems. We offer all our patients the following services, as needed:

  • A supportive team to handle all medical and mental health needs
  • A welcoming space to openly discuss and manage all related issues
  • Onsite psychology and social services
  • Neurocognitive testing

A Team Approach to Compassionate Care

Treating children and teens with non-conforming gender expression, genetic variations in the X and Y chromosomes, or those with differences in genital development can be complex and often requires a team of caregivers. Our board-certified endocrinologists understand the specialized expertise and multidisciplinary approach needed to care for your child.

CHOC specialists work together with you and your child to determine the best course of treatment. Your team may include CHOC experts from our many other specialties, such as cardiology, audiology, adolescent medicine, psychiatry, psychology and social work, plastic surgery and urology and more.

Related Video

Turner syndrome affects only females, and results when one of the X chromosomes is missing or partially missing. Dr. Mark Daniels discusses Turner syndrome and how it is treated in children and teens.

Klinefelter syndrome is a genetic condition affecting males when a boy is born with an extra coy of the X chromosome. Dr. Mark Daniels discusses Klinefelter syndrome and how it is treated in children and teens.

Pediatric urologist Dr. Tony Khoury explains disorders of sexual differentiation.

Pediatric endocrinologist Dr. Mark Daniels explains how to identify and understand gender dysphoria (formerly called gender disorder) in children and teens.

Transgender Awareness

Transgender and gender non-conforming youth are often socially isolated and at increased risk for depression, substance abuse and suicide, according to Dr. Terez Yonan, adolescent medicine specialist at CHOC. When they are respected, supported and cared for, these risks decrease significantly. In this article, Dr. Yonan offers five ways to support transgender and gender non-conforming family members, friends, classmates, teammates and neighbors.

Hands coming together in a circle


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CHOC Health Center, Centrum

Building: Centrum North | 1120 W. La Veta Ave. | Suite 125 | Orange, CA 92868 | 888-770-2462

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CHOC Clinic – Specialty Care

Building: CHOC Clinic | 1201 W. La Veta Ave. | Orange, CA 92868 | 888-770-2462