CHOC Research Institute

At CHOC, we know that research saves lives. That’s why our Research Institute has over 350 research studies in more than 30 specialties to provide your child with access to leading-edge treatments. Our scientists translate the latest advances in molecular profiling, including whole genome sequencing, to meet the individual needs of our patients at every stage of their young lives —from infancy through adolescence.

We understand that it’s important to conduct research directly with children and adolescents in a facility such as CHOC, that is devoted exclusively to the care, quality of life, rights and safety of children of all ages.


Clinical Trials

At CHOC, we are dedicated to providing patients the very latest breakthrough treatments available to children, adolescents and young adults. Our efforts bring hope to patients with rare conditions, or conditions not responding to traditional treatments.

(Currently, only oncology clinical trials are available online.)

Find a clinical trial

Search by trial name, protocol #, etc

or, view a list of all oncology clinical trials

About the CHOC Research Institute

The CHOC Research Institute was formally established in 2003, after years of active participation in pediatric clinical research. Today, the Research Institute supports more than 350 active human-subject research studies across nearly all of our pediatric subspecialty areas.

The Institute’s Sponsored Projects and Research Compliance offices administer and oversee federal NIH, California State CIRM, private foundation and donor funding in support of translational and clinical child health research.

CHOC’s affiliation with the University of California, Irvine and our active collaborations with top academic institutions from around the United States expand our access to leading-edge research projects and resources. Our patients, and indeed children worldwide, benefit from these diverse efforts – bringing breakthroughs from the lab to the bedside.

Research Institute Centers

CHOC Clinical Care and Research Attracts Patients Worldwide

Physician visiting with young girl patient in the hospitalEvery year, patients travel to CHOC to access care they can’t find anywhere else, including cutting-edge clinical trials. Their willingness to crisscross the globe to participate in these studies has placed the hospital on the map as a leading destination for innovative care.

One of these families is the McGregor family of Blackfalds, Alberta, Canada who found CHOC while searching for treatment alternatives for their 11-year-old daughter, Katharina (Katha). Katha has Niemann-Pick disease Type C (NP-C), a rare genetic disease that causes cholesterol to accumulate in the brain, lungs, liver and spleen, leading to deterioration and early death.

Since March 2016, Katha and her mother have traveled from Canada to CHOC every other week to participate in a yearlong clinical trial. While the travel is challenging, McGregor says it is definitely worthwhile. Read Katha’s story.

Nursing Research and Evidence-Based Care

Nurse at bedside of young smiling girl in the hospital

Nurses are the heart of CHOC’s staff and have the greatest opportunity to make a difference in patient care. They are dedicated to enhancing pediatric acute, critical and ambulatory care by striving for new and improved best practices. All CHOC RNs are encouraged to engage in research, evidence-based practice, innovation and quality improvement.

Research Professionals

The Research Institute is committed to delivering comprehensive service, from pre-award assistance to post-award management. We make every effort to accommodate individual researcher's needs and schedules within the resources of our office, and we act as an advocate for the faculty and the university in the research process.

Institutional Review Boards
CHOC currently has two Institutional Review Boards
Research Administration
CHOC's Research Administration office is a valuable resource for the CHOC community, providing expertise and highly specialized service in the important area of research management.
Proposal Preparation
Information you need for proposal preparation.

Stories of Innovative Pediatric Research

Infectious Disease Research

Pediatric Cancer and Genomics Research

Stem Cell Research

Imaging and Immunotherapy Research

Related Video

Dr. Phil Schwartz, CHOC senior scientist, explains how autism is currently is being diagnosed and how new new research may lead to diagnosing the disorder with a simple blood test.

Leonard Sender M.D., Medical Director of the Hyundai Cancer Institute at CHOC, talks about clinical trials for cancer patients.

In this video, Dr. Diane Nugent, CHOC medical director of hematology, talks about why research matters at CHOC and how this research helps children in our community.

Location and Contact Information


Location: CHOC Research Building – 4th Floor

Phone: 714-509-4341 | Fax: 714-509-4318