Dr. Anthony C. Chang, Chief Intelligence and Innovation Officer

Dr. Anthony C. Chang completed his undergraduate education with Bachelor of Arts in Molecular Biology at Johns Hopkins University (honors) and his Doctor of Medicine education at Georgetown University School of Medicine. He then completed his pediatric residency at National Children’s Hospital Medical Center and went on to his pediatric cardiology fellowship at Children’s Hospital of Philadelphia.

He was appointed a staff cardiologist at Boston Children’s Hospital with a position in the cardiac intensive care unit and later promoted to assistant professor at Harvard School of Medicine. He was later the medical director of the cardiac intensive care programs at Children’s Hospitals of Los Angeles and Miami Children’s Hospital. He is also formerly the medical director of pediatric cardiac in- tensive care service and chief of critical care cardiology at Texas Children’s Hospital and a tenured associate professor at Baylor College of Medicine. He served as director of the Heart Institute at the CHOC Hospital in Orange and division chief of the division of cardiology before becoming named as the Chief Intelligence and Innovation Officer at CHOC. He is the founder and medical director of the Medical Intelligence and Innovation

Institute (MI3) that is supported by the Sharon Disney Lund Foundation. The institute is dedicated to implement data science and artificial intelligence in medicine and is the first institute of its kind in a hospital. The new institute is concomitantly dedicated to facilitate innovation in children and health care all over the world. He is the organizing chair for the biennial Pediatrics2040: Emerging Trends and Future Innovations meeting as well as the founder and director of the Medical Intelligence and Innovation Summer Internship Program, which mentors close to 100 young physicians-to-be every summer. He has organized a pediatric innovation leadership group called the international Society for Pediatric Innovation (iSPI).

He intends to build a clinician-computer scientist interface to enhance all aspects of data science and artificial intelligence in health and medicine. He currently lectures widely on big data and artificial intelligence in medicine (he has been called “Dr. A.I.” by the Chicago Tribune and has given a TEDx talk as well as on the Singularity University faculty) (1). He has published review papers on big data and predictive analytics as well as machine learning and artificial intelligence in medicine (2)(3). He has completed a book project with a book series with Elsevier: Intelligence-Based Medicine: Principles and Applications of Artificial Intelligence in Clinical Medicine and Health Care and is the editor-in-chief of the journal of the same title. He is the founder and organizing chair of many Artificial Intelligence in Medicine (AI Med) meetings in the U.S. and abroad (Europe and Asia) that will focus on artificial intelligence in healthcare and medicine (www.aimed.io). He has launched a new society for clinicians with a special focus on data science and artificial intelligence as Medical Intelligence Society, or MIS. Finally, he is the dean of the nascent American Board of Artificial Intelligence in Medicine (ABAIM) offering education and certification of artificial intelligence in clinical medicine and health care as its mission.

He has a Masters in Business Administration (MBA) (in Health Care Administration) degree from the University of Miami and graduated with the McGaw Award for academic excellence. In addition, he has a Masters in Public Health (MPH) (in Health Care Policy) degree from University of California at Los Angeles and graduated with the Dean’s Award for academic excellence. He also holds a Masters in Biomedical Informatics (MS-BMI) from Stanford University.

He is the chief editor of the textbook Pediatric Cardiac Intensive Care and the past president-elect of the Pediatric Cardiac Intensive Care Society (PCICS). He is the chief editor of the textbook Heart Failure in Children and Young Adults. He is an associate editor of Pediatric Critical Care Medicine and is on the editorial board of Cardiology in the Young and Congenital Heart Today. He is a regular reviewer for Circulation, Pediatric Critical Care Medicine, Critical Care Medicine, and numerous other journals. He publishes and lectures widely on topics in pediatric cardiac intensive care, heart failure, sudden cardiac death, adult congenital heart disease, and other aspects of congenital heart disease and has been program directors for numerous large international conferences and symposia.

He is a member of the grant review committee for pediatric research at the National Institute of Health. He is also on the board of directors for the American Heart Association. He has been on the faculty of University of California at Los Angeles School of Public Health (eMPH program) and has taught global health at the eMPH program of the University of California at Los Angeles (UCLA). He also teaches pediatric cardiology to cardiology fellows and holds a volunteer faculty appointment at the School of Medicine at University of California at Los Angeles (UCLA). He will be teaching biomedical informatics at the University of California at Los Angeles (UCLA) Anderson School of Business and School of Nursing in the Spring of 2012.

He leads pediatric heart teams all over the world and recently mainly to Asia. He was one of the founding members of the Asia-Pacific Pediatric Cardiac Society (APPCS) and will be initiating the foundation arm of the society at the bequest of the board. He has been voted “Physician of Excellence” by the Orange County Medical Association and also selected as one of America’s “Top Doctors”, “Top Pediatricians”, and “Best Cardiologists” by several organizations.

  1. https://www.youtube.com/watch?v=Y5T8nckyuCA
  2. congenitalcardiologytoday.com/index_files/CCT-NOV12-NA.pdf
  3. congenitalcardiologytoday.com/index_files/CCT-APR13-NA.pd


  • Graduate Education – M.S. (Biomedical Informatics)
    Stanford University, Stanford, California
  • Graduate Education – M.P.H.
    University of California at Los Angeles School of Public Health, Los Angeles, California
  • Graduate Education – M.B.A (Healthcare Administration)
    University of Miami School of Business, Miami, Florida
  • Pediatric Cardiology Fellowship
    Children’s Hospital of Philadelphia, Pennsylvania
  • Pediatric Residency
    Children’s Hospital National Medical Center, Washington, DC
  • Medical School
    Georgetown University Medical School, Washington, DC

Administrative Appointments

  • Chief Intelligence and Innovation Officer, Medical Intelligence and Innovation Institute
  • Cardiology, CHOC Specialists

Honors and Awards

Dean’s Outstanding Scholarship Award (graduated first in class) and Delta Omega (Public Health Honor Society)
UCLA MPH Program and School of Public Health

Outstanding Teaching Award
UCLA Pediatric Cardiology Program

Professional Organizations

  • American Medical Association
  • American College of Cardiology
  • American Heart Association (Executive Vice President, Miami Chapter)
  • Society of Critical Care Medicine (scientific consultant)
  • Pediatric Cardiac Intensive Care Society (president-elect)
  • American College of Physician Executives (advanced standing)
  • American College of Healthcare Executives
  • American College of Medical Practice Management
  • American Society of Artificial Internal Organs

Primary Areas of Interest:

  • Artificial Intelligence in Clinical Medicine and Health Care
  • Innovation in Pediatric Health Care
  • Global and Public Health
  • Business and Healthcare Administration
  • Heart Failure in Children and Adults
  • Pediatric Cardiac Intensive Care

Our cardiologists commonly treat: 

  • Congenital heart defects
  • Chest pain
  • Heart murmur
  • Family history of heart disease
  • Hypertension, obesity and lipid management
  • Syncope and palpitations
  • Sports cardiology
  • Cardiac genetics
  • Cardiomyopathy
  • Chronic lung disease

Published Works

Chang AC, Morell J, Rebolledo M.
Ten Innovative Concepts for the Pediatric Cardiology Clinical Service.
Congenital Cardiology Today, May 2012.

Chang AC, Musen M.
Artificial Intelligence in Pediatric Cardiology: An Innovative Transformation
In Patient Care, Clinical Research, and Medical Education.
Congenital Cardiology Today, November 2012

Inayat M, Yeasted R, Schultz E, Cleary J, Chang A.
Bosentan Role in Severe Refractory Pulmonary Hypertension in an
Extremely Low Birth Weight Infant.

Perry J, Lanzberg M, Franklin W, Webb G, Chang A.
Cardiac Intensive Care of the Adult with Congenital Heart Disease: Basic
Principles in the Management of Common Problems.

Wang R, Covault K, Halcrow E, Gardner A, Cao X, Newcomb R, Dauben R,
Chang A.
Carotid intima-media thickness is increased in patients with

Chang A.
Big Data in Pediatric Cardiology: The Upcoming Knowledge Revolution.
Congenital Cardiology Today, April 2013.


CHOC Specialists – Cardiology
505 S. Main Street
Suite 600
Orange, CA 92868
phone: 714-509-3939
fax: 714-509-3949

CHOC Hospital
1201 W. La Veta Ave.
Orange, CA 92868-3874

CHOC at Mission Hospital
27700 Medical Center Rd
Mission Viejo, CA 92691

Sea View Pediatrics
23521 Paseo de Valencia
Suite 200
Laguna Hills, CA 92654

Irvine Pediatrics
16300 Sand Canyon Ave
Suite 811
Irvine, CA 92618

Hoag Memorial Presbyterian Hospital
1 Hoag Drive
Newport Beach, CA 92663

Western Medical Center
1001 N Tustin Ave
Santa Ana, CA 92705

CHOC Health Center in Corona
854 Magnolia Ave
Suite 101
Corona, CA 92879

Anaheim Regional Medical Center
1111 W La Palma Ave
Anaheim, CA 92801

St Jude Medical Center
101 E Valencia Mesa Dr
Fullerton, CA 92835

PIH Health Family Practice Center
12291 Washington Blvd
Suite 500
Whittier, CA 90606

10833 Le Conte Ave
Los Angeles, CA 90024

  • Anthony C Chang MD, MBA, MPH, MS
    • Appointments:
    • Office: 714-509-3939
    • Specialty: Cardiology
    • Board Certified: Pediatric Cardiology
    • On Staff at: CHOC Children's Hospital and CHOC Children's at Mission Hospital


Dr. Anthony Chang takes pleasure in seeing his patients grow

Being a Doctor: Dr. Chang

Being a doctor, Dr. Anthony Chang tells us about the pleasure he gets from seeing his small patients grow up to be adults.

Dr. Chang speaking about stimulants and the effects on the heart

Stimulants and the Effects on the Heart: Dr. Chang

Stimulants and the effects on the heart is the topic in this video with Dr. Anthony Chang. He tells when a medication indicates there is a stimulant inside.

Dr. Anthony Chang - increase of sudden cardiac arrest in athletes

LEAPS: Dr. Chang

Dr. Anthony Chang discusses Life-threatening Events Associated with Pediatric Patients in Sports (LEAPS) & the increase of sudden cardiac death in young athletes in O.C.


Spyro Mousses, Ph.D., Dr. Leonard Sender, and Dr. Anthony Chang in Seacrest Studio

Impact of Precision Medicine on Oncology Field

Precision medicine is changing how physicians think about treatments, with great advances coming out of the oncology field. In podcast No. 42, three CHOC experts and speakers at the upcoming Peds2040 conference.