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Dr. Anthony C. Chang, MBA, MPH, MS, Pediatric Cardiology

Chief Intelligence and Innovation Officer, Sharon Disney Lund Medical Intelligence and Innovation Institute (MI3) at CHOC Children’s

Dr. Chang attended Johns Hopkins University for his B.A. in molecular biology prior to entering Georgetown University School of Medicine for his M.D. He then completed his pediatric residency at Children’s Hospital National Medical Center and his pediatric cardiology fellowship at the Children’s Hospital of Philadelphia.

He accepted a position as attending cardiologist in the cardiovascular intensive care unit of Boston Children’s Hospital and as assistant professor at Harvard Medical School. He has been the medical director of several pediatric cardiac intensive care programs (including Children’s Hospital of Los Angeles, Miami Children’s Hospital, and Texas Children’s Hospital) and is currently the Chief Intelligence and Innovation Officer and Medical Director of the Heart Failure Program at Children’s Hospital of Orange County. He has also been repeatedly named Physician of Excellence by the Orange County Medical Association.

He is known for several innovations in pediatric cardiac care, including introducing the cardiac drug milrinone and co-designing (with Dr. Michael DeBakey) an axial-type ventricular assist device in children. He has helped to build a successful cardiology practice as a company and was able to complete a deal on Wall Street. He is a committee member of the National Institute of Health pediatric grant review committee. He is also the editor of several textbooks in pediatric cardiology, including Pediatric Cardiac Intensive Care, Heart Failure in Children and Young Adults, and Pediatric Cardiology Board Review.

He is the founder of the Pediatric Cardiac Intensive Care Society (PCICS) that launched the multi-disciplinary focus on cardiac intensive care for children. He is also the founder of the Asia-Pacific Pediatric Cardiac Society (APPCS), which united pediatric cardiologists and cardiac surgeons from 24 Asian countries and launched a biennial meeting in Asia that now draws over 1,000 attendees.

He has completed a Masters in Business Administration (MBA) in Health Care Administration at the University of Miami School of Business and graduated with the McCaw Award of Academic Excellence. He also completed a Masters in Public Health (MPH) in Health Care Policy at the Jonathan Fielding School of Public Health of the University of California, Los Angeles and graduated with the Dean’s Award for Academic Excellence. Finally, he completed his Masters of Science (MS) in Data Science with a sub-specialization in artificial intelligence from Stanford School of Medicine. He is also a computer scientist-in-residence at Chapman University.

He is the founder and medical director of the nascent Medical Intelligence and Innovation Institute (MI3) that is supported by the Sharon Disney Lund Foundation. The institute is dedicated to implement data science and artificial intelligence in medicine and is the first institute of its kind in a hospital. The new institute is concomitantly dedicated to facilitate innovation in children and health care all over the world. He is the organizing chair for the biennial Pediatrics2040: Emerging Trends and Future Innovations meeting as well as the founder of the Medical Intelligence and Innovation Summer Internship Program, which mentors close to 100 young physicians-to-be every summer. He has organized a pediatric innovation leadership group and has started the international Society for Pediatric Innovation (iSPI) with 30 charter members.

He intends to build a clinician-computer scientist interface to enhance all aspects of data science and artificial intelligence in health and medicine. He currently lectures widely on big data and artificial intelligence in medicine (he has been called “Dr. A.I.” and has given a TEDx talk and on the faculty of Singularity University)( ). He has also published review papers on big data and predictive analytics as well as machine learning and artificial intelligence in medicine ( )( ). He is currently organizing a book project, Medical Intelligence: Big Data, Predictive Analytics, Cognitive Computing, Machine and Deep Learning and Artificial Intelligence in Medicine. He is also the organizing chair for Artificial Intelligence in Medicine (AIMed) annual meeting, the largest meeting that focuses on applications of artificial intelligence in medicine. He is the co-founder and CEO of a startup company (CardioGenomic Intelligence, LLC) that focuses on artificial intelligence applications such as deep learning in clinical cardiology and genomic medicine.

Administrative Appointments

  • Chief Intelligence and Innovation Officer, CHOC Children’s
  • Cardiology, CHOC Children’s Specialists

Education

  • Graduate Education – M.S. (Biomedical Informatics) (in progress)
    Stanford University, Stanford, California
  • Graduate Education – M.P.H.
    University of California at Los Angeles School of Public Health, Los Angeles, California
  • Graduate Education – M.B.A (Healthcare Administration)
    University of Miami School of Business, Miami, Florida
  • Pediatric Cardiology Fellowship
    Children’s Hospital of Philadelphia, Pennsylvania
  • Pediatric Residency
    Children’s Hospital National Medical Center, Washington, DC
  • Medical School
    Georgetown University Medical School, Washington, DC

Honors and Awards

Dean’s Outstanding Scholarship Award (graduated first in class) and Delta Omega (Public Health Honor Society)
UCLA MPH Program and School of Public Health

Outstanding Teaching Award
UCLA Pediatric Cardiology Program

Professional Organizations

  • American Medical Association
  • American College of Cardiology
  • American Heart Association (Executive Vice President, Miami Chapter)
  • Society of Critical Care Medicine (scientific consultant)
  • Pediatric Cardiac Intensive Care Society (president-elect)
  • American College of Physician Executives (advanced standing)
  • American College of Healthcare Executives
  • American College of Medical Practice Management
  • American Society of Artificial Internal Organs

Our cardiologists commonly treat: 

  • Congenital heart defects
  • Chest pain
  • Heart murmur
  • Family history of heart disease
  • Hypertension, obesity and lipid management
  • Syncope and palpitations
  • Sports cardiology
  • Cardiac genetics
  • Cardiomyopathy
  • Chronic lung disease

Published Works

Chang AC, Morell J, Rebolledo M.
Ten Innovative Concepts for the Pediatric Cardiology Clinical Service.
Congenital Cardiology Today, May 2012.

Chang AC, Musen M.
Artificial Intelligence in Pediatric Cardiology: An Innovative Transformation
In Patient Care, Clinical Research, and Medical Education.
Congenital Cardiology Today, November 2012

Inayat M, Yeasted R, Schultz E, Cleary J, Chang A.
Bosentan Role in Severe Refractory Pulmonary Hypertension in an
Extremely Low Birth Weight Infant.

Perry J, Lanzberg M, Franklin W, Webb G, Chang A.
Cardiac Intensive Care of the Adult with Congenital Heart Disease: Basic
Principles in the Management of Common Problems.

Wang R, Covault K, Halcrow E, Gardner A, Cao X, Newcomb R, Dauben R,
Chang A.
Carotid intima-media thickness is increased in patients with
Mucopolysaccharidoses

Chang A.
Big Data in Pediatric Cardiology: The Upcoming Knowledge Revolution.
Congenital Cardiology Today, April 2013.

Locations

CHOC Children’s Specialists – Cardiology
505 S. Main Street
Suite 200
Orange, CA 92868
phone: 714-509-3939
fax: 714-509-3949

CHOC Children’s Hospital
1201 W. La Veta Ave.
Orange, Ca 92868-3874

CHOC Children’s at Mission Hospital
27700 Medical Center Rd
Mission Viejo, CA 92691Sea View Pediatrics
23521 Paseo de Valencia
Suite 200
Laguna Hills, CA 92654

Irvine Pediatrics
16300 Sand Canyon Ave
Suite 811
Irvine, CA 92618

Hoag Memorial Presbyterian Hospital
1 Hoag Drive
Newport Beach, CA 92663Western Medical Center
1001 N Tustin Ave
Santa Ana, CA 92705

CHOC Children’s Health Center in Corona
854 Magnolia Ave
Suite 101
Corona, CA 92879

Anaheim Regional Medical Center
1111 W La Palma Ave
Anaheim, CA 92801

St Jude Medical Center
101 E Valencia Mesa Dr
Fullerton, CA 92835

PIH Family Practice Center
12291 Washington Blvd
Suite 500
Whittier, CA 90606

UCLA
10833 Le Conte Ave
Los Angeles, CA 90024

  • Anthony C Chang MD
    • Appointments:
      888-770-2462
    • Office: 714-509-3939
    • Specialty: Cardiology
    • Board Certified: Pediatric Cardiology
    • On Staff at: CHOC Children's Hospital and CHOC Children's at Mission Hospital

Videos

Being a Doctor: Dr. Chang

Being a doctor, Dr. Anthony Chang tells us about the pleasure he gets from seeing his small patients grow up to be adults.

Stimulants and the Effects on the Heart: Dr. Chang

Stimulants and the effects on the heart is the topic in this video with Dr. Anthony Chang. He tells when a medication indicates there is a stimulant inside.

LEAPS: Dr. Chang

Dr. Anthony Chang discusses Life-threatening Events Associated with Pediatric Patients in Sports (LEAPS) & the increase of sudden cardiac death in young athletes in O.C.

Podcasts

Impact of Precision Medicine on Oncology Field

Precision medicine is changing how physicians think about treatments, with great advances coming out of the oncology field. In podcast No. 42, three CHOC experts and speakers at the upcoming Peds2040 conference.

Learn more about Dr. Chang and Pediatric Cardiology

Long Live Childhood

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