Dr. Anthony C. Chang, Chief Intelligence and Innovation Officer

Dr. Anthony Chang attended Johns Hopkins University for his B.A. in molecular biology prior to entering Georgetown University School of Medicine for his M.D. He then completed his pediatric residency at Children’s Hospital National Medical Center and his pediatric cardiology fellowship at the Children’s Hospital of Philadelphia. He  accepted a position as attending cardiologist in the cardiovascular intensive care unit of Boston Children’s Hospital and as assistant professor at Harvard Medical School.

He has been the medical director of several pediatric cardiac intensive care programs (including Children’s Hospital of Los Angeles, Miami Children’s Hospital, and Texas Children’s Hospital). He served as the medical director of the Heart Institute at Children’s Hospital of Orange County.

He is currently the Chief Intelligence and Innovation Officer (CIIO) and Medical Director of the Heart Failure Program at Children’s Hospital of Orange County. He has also been named a Physician of Excellence by the Orange County Medical Association and Top Cardiologist, Top Doctor for many years as well as one of the nation’s Top Innovators in Healthcare.

He completed a Masters in Business Administration (MBA) in Health Care Administration at the University of Miami School of Business and graduated with the McCaw Award of Academic Excellence. He also completed a Masters in Public Health (MPH) in Health Care Policy at the Jonathan Fielding School of Public Health of the University of California, Los Angeles and graduated with the Dean’s Award for Academic Excellence. He later taught Global Health there. Finally, he graduated with his Masters of Science (MS) in Biomedical Data Science with a subarea focus in artificial intelligence from the Stanford School of Medicine and has completed a certification on artificial Intelligence from MIT. He is a computer scientist-in-residence and a member of the Dean’s Scientific Council at Chapman University.

Dr. Chang has helped to build a successful cardiology practice as a startup company and was able to complete a deal on Wall Street. He is known for several innovations in pediatric cardiac care, including introducing the cardiac drug milrinone and co-designing (with Dr. Michael DeBakey) an axial-type ventricular assist device in children. He is a member of the National Institute of Health pediatric grant review committee. He is the editor of several textbooks in pediatric cardiology, including; Pediatric Cardiac Intensive Care, Heart Failure in Children and Young Adults, and Pediatric Cardiology Board Review.

He is the founder of the Pediatric Cardiac Intensive Care Society (PCICS) that launched the multi-disciplinary focus on cardiac intensive care for children. He is also the founder of the Asia-Pacific Pediatric Cardiac Society (APPCS), which united pediatric cardiologists and cardiac surgeons from 24 Asian countries and launched a biennial meeting in Asia that now draws over 1,000 attendees.  Dr. Chang is on the board of Cardiology in the Young and Congenital Heart Today. He is a regular reviewer for Circulation, Pediatric Critical Care Medicine, Critical Care Medicine, and numerous other journals. He publishes and lectures widely on topics in pediatric cardiac intensive care, heart failure, sudden cardiac death, adult congenital heart disease, and other aspects of congenital heart disease and has been program directors for numerous large international conferences and symposia.

Dr. Chang is the founder and medical director of the Medical Intelligence and Innovation Institute (MI3) that is supported by the Sharon Disney Lund Foundation. The institute is dedicated to implement data science and artificial intelligence in medicine and is the first institute of its kind in a hospital. The new institute is concomitantly dedicated to facilitating innovation in children and health care all over the world. He is the organizing chair for the biennial Pediatrics2040: Emerging Trends and Future Innovations meeting as well as the founder and director of the Medical Intelligence and Innovation Summer Internship Program, which mentors close to 100 young physicians-to-be every summer. He has organized a pediatric innovation leadership group called the international Society for Pediatric Innovation (iSPI).

He intends to build a clinician-computer scientist interface to enhance all aspects of data science and artificial intelligence in health and medicine. He currently lectures widely on big data and artificial intelligence in medicine (he has been called “Dr. A.I.” by the Chicago Tribune and has given a TEDx talk as well as on the Singularity University faculty) ( 1). He has published review papers on big data and predictive analytics as well as machine learning and artificial intelligence in medicine ( 2)( 3). He has published a text book along planned to be a book series with Elsevier titled: “Intelligence-Based Medicine: Principles and Applications of Artificial Intelligence in Clinical Medicine and Health Care” (with plans for a book series) and is the editor-in-chief of the journal of the same title. He is the founder and organizing chair of many Artificial Intelligence in Medicine (AI Med) meetings in the U.S. and abroad (Europe and Asia) that focus on artificial intelligence in healthcare and medicine (www.ai-med.io). He is the founder of a healthcare AI consulting firm, Medical Intelligence 10 (MI10). He has started a society for clinicians with a special focus on data science and artificial intelligence known as the Medical Intelligence Society, or MIS. He is the dean of the nascent American Board of Artificial Intelligence in Medicine (ABAIM) that offers education and certification of artificial intelligence in clinical medicine and health care as its mission. Finally, Dr. Chang serves as the leader of the Orange County Chapter for the Society of Physician Entrepreneurs (SoPE).

He is the founder of three startup companies in artificial intelligence in medicine:

1)    CardioGenomic Intelligence (CGI), LLC is a multifaceted company that focuses on artificial intelligence applications such as deep learning in clinical cardiology (cardiomyopathy and heart failure as well as other cardiovascular disease) and genomic medicine.
2)    Artificial Intelligence in Medicine (AIMed), LLC is an events company that organizes meetings and educational programs in artificial intelligence in medicine in local as well as global venues.
3)    Medical Intelligence 10 (MI10), LLC is an education and consulting/advising conglomerate for executives and physician leaders as well as investors for the evaluation and implementation of AI strategies in healthcare organizations, for evaluation and recommendation of AI in healthcare vendors, and assessment and implementation of cybersecurity in healthcare organizations.

1.    https://www.youtube.com/watch?v=Y5T8nckyuCA
2.    congenitalcardiologytoday.com/index_files/CCT-NOV12-NA.pdf
3.    congenitalcardiologytoday.com/index_files/CCT-APR13-NA.pdf


  • Graduate Education – M.D.
    Georgetown University School of Medicine, Washington D.C.
  • Graduate Education – M.S. (Biomedical Informatics)
    Stanford University, Stanford, California
  • Graduate Education – M.P.H.
    University of California at Los Angeles School of Public Health, Los Angeles, California
  • Graduate Education – M.B.A (Healthcare Administration)
    University of Miami School of Business, Miami, Florida
  • Pediatric Cardiology Fellowship
    Children’s Hospital of Philadelphia, Pennsylvania
  • Pediatric Residency
    Children’s Hospital National Medical Center, Washington, DC

Administrative Appointments

  • Chief Intelligence and Innovation Officer, Medical Intelligence and Innovation Institute
  • Cardiology, CHOC Specialists

Honors and Awards

Dean’s Outstanding Scholarship Award (graduated first in class) and Delta Omega (Public Health Honor Society)
UCLA MPH Program and School of Public Health

Outstanding Teaching Award
UCLA Pediatric Cardiology Program

Professional Organizations

  • American Medical Association
  • American College of Cardiology
  • American Heart Association (Executive Vice President, Miami Chapter)
  • Society of Critical Care Medicine (scientific consultant)
  • Pediatric Cardiac Intensive Care Society (president-elect)
  • American College of Physician Executives (advanced standing)
  • American College of Healthcare Executives
  • American College of Medical Practice Management
  • American Society of Artificial Internal Organs

Primary Areas of Interest:

  • Artificial Intelligence in Clinical Medicine and Health Care
  • Innovation in Pediatric Health Care
  • Global and Public Health
  • Business and Healthcare Administration
  • Heart Failure in Children and Adults
  • Pediatric Cardiac Intensive Care

Our cardiologists commonly treat: 

  • Congenital heart defects
  • Chest pain
  • Heart murmur
  • Family history of heart disease
  • Hypertension, obesity and lipid management
  • Syncope and palpitations
  • Sports cardiology
  • Cardiac genetics
  • Cardiomyopathy
  • Chronic lung disease

Published Works

Chang AC, Morell J, Rebolledo M.
Ten Innovative Concepts for the Pediatric Cardiology Clinical Service.
Congenital Cardiology Today, May 2012.

Chang AC, Musen M.
Artificial Intelligence in Pediatric Cardiology: An Innovative Transformation
In Patient Care, Clinical Research, and Medical Education.
Congenital Cardiology Today, November 2012

Inayat M, Yeasted R, Schultz E, Cleary J, Chang A.
Bosentan Role in Severe Refractory Pulmonary Hypertension in an
Extremely Low Birth Weight Infant.

Perry J, Lanzberg M, Franklin W, Webb G, Chang A.
Cardiac Intensive Care of the Adult with Congenital Heart Disease: Basic
Principles in the Management of Common Problems.

Wang R, Covault K, Halcrow E, Gardner A, Cao X, Newcomb R, Dauben R,
Chang A.
Carotid intima-media thickness is increased in patients with

Chang A.
Big Data in Pediatric Cardiology: The Upcoming Knowledge Revolution.
Congenital Cardiology Today, April 2013.

Chang AC. Primary prevention of sudden cardiac death of the young athlete: the controversy about the screening electrocardiogram and its innovative artificial intelligence solution. Pediatric Cardiology 2012

Chang AC. Determination of cardiac output in critically ill children: are we any closer to the ideal methodology. Pediatric Critical Care Medical 2012

Li SC, Acevedo J, Wang L, Jiang H, Luo J, Pestell RG, Loudon WG, Chang AC. Mechanisms for progenitor cell-mediated repair for ischemic heart injury. Current Stem Cell Respiratory Therapy. 2012 Jan

Chang AC, Hunt J. Toward unreasonable effectiveness of cardiac ICU data: artificial intelligence in pediatric cardiac intensive care. Pediatric Critical Care Medicine. 2014 Jul

Wang RY, Chang RC, Sowa ME, Chang AC, Abdenur JE. Prevention of metabolic decompensation in an infant with mutase deficient methylmalonic aciduria undergoing cardiopulmonary bypass. World Journal of Pediatrics. 2014 Feb

Maher KO, Chang AC, Shin A, Hunt J, Wong HR. Innovation in Pediatric Cardiac Intensive Care: An Exponential Convergence Toward Transformation of Care. World Journal Pediatrics Congenital Heart Surgery. 2015 Oct

Gupta P, Rettiganti M, Fisher PL, Chang AC, Rice TB, Wetzel RC. Association of Freestanding Children’s Hospitals With Outcomes in Children With Critical Illness. Critical Care Medicine. 2016 Dec

Checchia PA, Laussen PC, Macrae D, Bohn D, Chang AC, Wessel DL. Pediatric Cardiac Intensive Care: A Transition to Maturity. Pediatric Critical Care Medicine. 2016 Aug;17(8 Suppl 1):S110-1

Mikhael M, Cleary JP, Dhar V, Chen Y, Nguyen DV, Chang AC. Birth Tourism and Neonatal Intensive Care: A Children’s Hospital Experience. American Journal Perinatol. 2016 Dec;33(14):1415-1419.

Pasquali SK, Jacobs JP, Farber GK, Bertoch D, Blume ED, Burns KM, Campbell R, Chang AC, Chung WK, Riehle-Colarusso T, Curtis LH, Forrest CB, Gaynor WJ, Gaies MG, Go AS, Henchey P, Martin GR, Pearson G, Pemberton VL, Schwartz SM, Vincent R, Kaltman JR. Report of the National Heart, Lung, and Blood Institute Working Group: An Integrated Network for Congenital Heart Disease Research. Circulation. 2016 Apr 5

Pick JM, Ellis ZD, Alejos JC, Chang AC. Rapidly progressive heart failure requiring transplantation in muscular dystrophy: a need for frequent screening. Cardiology in the Young. 2017 Nov

Shu LQ, Sun YK, Tan LH, Shu Q, Chang AC. Application of artificial intelligence in pediatrics: past, present and future. World Journal of Pediatrics. 2019 Apr

Gearhart AS, Raymundo SA, Chang AC. Echocardiographic MRI: an innovative fusion of functional and anatomic assessment strategy for CHD. Cardiology in the Young. 2019 Jan

Chang A. Precision Intensive Care: A Real-Time Artificial Intelligence Strategy for the Future. Pediatr Crit Care Med. 2019

Shu LQ, Sun YK, Tan LH, Shu Q, Chang AC. Application of artificial intelligence in pediatrics: past, present and future. World J Pediatr. 2019

Chang AC. Artificial intelligence in pediatric cardiology and cardiac surgery: Irrational hype or paradigm shift? Ann Pediatr Cardiol. 2019 Sep-Dec

Ehwerhemuepha L, Pugh K, Grant A, Taraman S, Chang A, Rakovski C, Feaster W. A Statistical-Learning Model for Unplanned 7-Day Readmission in Pediatrics.Hosp Pediatr. 2020 Jan

Zheng J, Chu H, Struppa D, Zhang J, Yacoub SM, El-Askary H, Chang A, Ehwerhemuepha L, Abudayyeh I, Barrett A, Fu G, Yao H, Li D, Guo H, Rakovski C. Optimal Multi-Stage Arrhythmia Classification Approach. Sci Rep. 2020 Feb 19

Ehwerhemuepha L, Gasperino G, Bischoff N, Taraman S, Chang A, Feaster W. HealtheDataLab – a cloud computing solution for data science and advanced analytics in healthcare with application to predicting multi-center pediatric readmissions. BMC Med Inform Decis Mak. 2020 Jun 19

Gearhart A, Gaffar S, Chang AC. A primer on artificial intelligence for the paediatric cardiologist. Cardiol Young. 2020 Jul

Gaffar S, Gearhart AS, Chang AC. The Next Frontier in Pediatric Cardiology: Artificial Intelligence. Pediatr Clin North Am. 2020 Oct

Lei H, O’Connell R, Ehwerhemuepha L, Taraman S, Feaster W, Chang A. Agile clinical research: A data science approach to scrumban in clinical medicine. Intell Based Med. 2020 Dec

Chang A. Intelligence-based medicine: Medici Effect of the modern medical era. Intell Based Med. 2020 Nov

Chang AC. Artificial intelligence and COVID-19: Present state and future vision. Intell Based Med. 2020 Dec

Hoenk K, Torno L, Feaster W, Taraman S, Chang A, Weiss M, Pugh K, Anderson B, Ehwerhemuepha L. Multicenter study of risk factors of unplanned 30-day readmissions in pediatric oncology. Cancer Rep (Hoboken). 2021 Jun

Shortliffe EH, Peleg M, Combi C, Chang AC, Vinci J. Publishing artificial intelligence research papers: A tale of three journals. J Biomed Inform. 2021 Mar

Shortliffe EH, Peleg M, Combi C, Chang AC, Vinci J. Publishing Artificial Intelligence Research Papers: A Tale of Three Journals. Artif Intell Med. 2021 Mar

Zheng J, Fu G, Abudayyeh I, Yacoub M, Chang A, Feaster WW, Ehwerhemuepha L, El-Askary H, Du X, He B, Feng M, Yu Y, Wang B, Liu J, Yao H, Chu H, Rakovski C. A High-Precision Machine Learning Algorithm to Classify Left and Right OutflowTract Ventricular Tachycardia. Front Physiol. 2021 Feb 25

Ehwerhemuepha L, Danioko S, Verma S, Marano R, Feaster W, Taraman S, Moreno T, Zheng J, Yaghmaei E, Chang A. A super learner ensemble of 14 statistical learning models for predicting COVID-19 severity among patients with cardiovascular conditions. Intell Based Med. 2021

Sanger T, Chang A, Feaster W, Taraman S, Afari N, Beauregard D, Dethlefs B, Ghere T, Kabeer M, Tolomiczenko G, Billig M, Brophy J, Eskandanian K, Espinoza J, Farrugia S, Harrison M, Horvat C, Hoyen C, Koh C, Komiyama A, Nelson K, Kulkarni O, Levy R, Maher K, O’Donnell M, Ponsky T, Richmond F, Richter J, Roy S, Samir S,Suresh S, Stallworth C, Thekkedath U, Toman K, Wall J, West L, Wolff D. Opportunities for Regulatory Changes to Promote Pediatric Device Innovation in the United States: Joint Recommendations From Pediatric Innovator Roundtables. IEEE J Transl Eng Health Med. 2021 Jun 25


CHOC Specialists – Cardiology
505 S. Main Street
Suite 600
Orange, CA 92868
phone: 714-509-3939
fax: 714-509-3949

CHOC Hospital
1201 W. La Veta Ave.
Orange, CA 92868-3874

CHOC at Mission Hospital
27700 Medical Center Rd
Mission Viejo, CA 92691

Sea View Pediatrics
23521 Paseo de Valencia
Suite 200
Laguna Hills, CA 92654

Irvine Pediatrics
16300 Sand Canyon Ave
Suite 811
Irvine, CA 92618

Hoag Memorial Presbyterian Hospital
1 Hoag Drive
Newport Beach, CA 92663

Western Medical Center
1001 N Tustin Ave
Santa Ana, CA 92705

CHOC Health Center in Corona
854 Magnolia Ave
Suite 101
Corona, CA 92879

Anaheim Regional Medical Center
1111 W La Palma Ave
Anaheim, CA 92801

St Jude Medical Center
101 E Valencia Mesa Dr
Fullerton, CA 92835

PIH Health Family Practice Center
12291 Washington Blvd
Suite 500
Whittier, CA 90606

10833 Le Conte Ave
Los Angeles, CA 90024

  • Anthony C Chang M.D., M.B.A., M.P.H., M.S
    • Appointments:
    • Office: 714-509-3939
    • Specialty: Cardiology
    • Board Certified: Pediatric Cardiology
    • On Staff at: CHOC Hospital in Orange and CHOC at Mission Hospital


Dr. Anthony Chang takes pleasure in seeing his patients grow

Being a Doctor: Dr. Chang

Being a doctor, Dr. Anthony Chang tells us about the pleasure he gets from seeing his small patients grow up to be adults.

Dr. Chang speaking about stimulants and the effects on the heart

Stimulants and the Effects on the Heart: Dr. Chang

Stimulants and the effects on the heart is the topic in this video with Dr. Anthony Chang. He tells when a medication indicates there is a stimulant inside.

Dr. Anthony Chang - increase of sudden cardiac arrest in athletes

LEAPS: Dr. Chang

Dr. Anthony Chang discusses Life-threatening Events Associated with Pediatric Patients in Sports (LEAPS) & the increase of sudden cardiac death in young athletes in O.C.


Spyro Mousses, Ph.D., Dr. Leonard Sender, and Dr. Anthony Chang in Seacrest Studio

Impact of Precision Medicine on Oncology Field

Precision medicine is changing how physicians think about treatments, with great advances coming out of the oncology field. In podcast No. 42, three CHOC experts and speakers at the upcoming Peds2040 conference.