CHOC Children's - Clinical Trials

Hyundai Cancer Institute :: Clinical Trials

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The Hyundai Cancer Institute at CHOC Children's, a member of the Children’s Oncology Group, provides patients with access to state-of-the-art clinical research trials. A clinical trial is a research study that aims to determine the most effective treatment for a particular disease. Each trial is a result of a very detailed study of factors associated with the most current standard treatment and variables that may lead to an improvement in survival rates or a reduction in side effects or late effects of treatment.

Through our Childrens Oncology Group (COG) membership, the Hyundai Cancer Institute at CHOC Children's received a prestigious Phase I clinical trial designation, making us one of only 22 facilities in North America offering COG's groundbreaking alternative treatments.

For more information on participation in clinical trials, contact the CHOC Research Institute at (714) 509-4341.

Search Results:

Category: Oncology
IRB Code: 110876
Study Title: 10-CBA: A multicenter access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs)for transplantation in pediatric and adult patients with hematologic malignancies and other indications
Category: Oncology
IRB Code: 120542
Study Title: A Hyundai Cancer Institute Pilot Protocol to Determine the Incidence of Vitamin D Deficiency in Newly Diagnosed Pediatric Acute Lymphoblastic Leukemia (ALL) Patients
Category: Oncology
IRB Code: 809104
Study Title: A Multi-Center, Multi-National, Historical Cohort Controlled Study to Evaluate Efficacy and Safety of Transplantation of StemEx?, Umbilical Cord Blood Stem and Progenitor Cells Expanded Ex Vivo, in Subjects with Hematologic Malignancies following Myeloablative Therapy
Category: Oncology
IRB Code: 120104
Study Title: A multi-center, open-label, pharmacokinetic study of oral nilotinib in pediatric patients with Gleevac (imatinib)-resistant/intolerant Ph CML chronic phase (CP) or accelerated phase (AP) or with refractory/relapsed Ph ALL
Category: Oncology
IRB Code: 100655
Study Title: A Phase I Trial for Refractory or Relapsed Neuroblastoma with DFMO Alone and in Combination with Etoposide
Category: Oncology
IRB Code: 1011113
Study Title: A phase I/II, open-label, dose-escalating study to evaluate the safety, tolerability and pharmacokinetics of twice daily oral midostaurin and to evaluate the preliminary clinical and pharmacodynamic response in pediatric patients with relapsed or refractory leukemia
Category: Oncology
IRB Code: 90325
Study Title: A Phase II Study of Dasatinib Therapy in Children and Adolescents with Newly Diagnosed Chronic Phase CML or with Ph+ Leukemias Resistant or Intolerant to Imatinib
Category: Oncology
IRB Code: 110670
Study Title: A Phase III, Randomized, Double-Blind, Active Comparator-Controlled Clinical Trial, Conducted Under In-House Blinding Conditions, to Examine the Efficacy and Safety of Aprepitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting (CINV) in Pediatric Patients
Category: Oncology
IRB Code: 90652
Study Title: AALL0433, Intensive Treatment for Intermediate-Risk Relapse of Childhood B-Precursor Acute Lymphoblastic Leukemia (ALL): A Randomized Trial of Vincristine Strategies
Category: Oncology
IRB Code: 70327
Study Title: AALL0434 Intensified Methotrexate, Nelarabine (Compound 506U78; IND# 52611) and Augmented BFM Therapy for Children and Young Adults with Newly Diagnosed T-cell Acute Lymphoblastic Leukemia (ALL) or T-cell Lymphoblastic Lymphoma
Category: Oncology
IRB Code: 80221
Study Title: AALL0631, A Phase III Study of Risk Directed Therapy for Infants with Acute Lymphoblastic Leukemia (ALL): Randomization of Highest Risk Infants to Intensive Chemotherapy +/- FLT3 Inhibition (CEP-701, Lestaurtinib; IND#76431; NSC#617807)
Category: Oncology
IRB Code: 70745
Study Title: AALL06N1 A Study of Neurocognitive Function in Children Treated for ALL.
Category: Oncology
IRB Code: 90324
Study Title: AALL07P1 A Phase II Pilot Trial of Bortezomib (PS-341, Velcade, IND# 58,443 ) in Combination with Intensive Re-Induction Therapy for Children with Relapsed Acute Lymphoblastic Leukemia (ALL) and Lymphoblastic Lymphoma (LL)
Category: Oncology
IRB Code: 100878
Study Title: AALL08B1, Classification of Newly Diagnosed Acute lymphoblastic Leukemia (ALL)
Category: Oncology
IRB Code: 100880
Study Title: AALL0932, Treatment of Patients with Newly Diagnosed Standard Risk B-Precursor Acute Lymphoblastic Leukemia (ALL)
Category: Oncology
IRB Code: 120326
Study Title: AALL1131, A Phase III Randomized Trial for Newly Diagnosed High Risk B-precursor Acute Lymphoblastic Leukemia (ALL) Testing Clofarabine (IND# 73789, NSC# 606869) in the Very High Risk Stratum
Category: Oncology
IRB Code: 90995
Study Title: AAML0631 Risk Adapted Treatment of Newly Diagnosed Childhood Acute Promyelocytic Leukemia (APL) using Arsenic Trioxide (Trisenox, IND#103,331) during Consolidation
Category: Oncology
IRB Code: 90651
Study Title: AAML08B1; Biology Study of Transient Myeloproliferative Disorder (TMD) in Children with Down Syndrome (DS)
Category: Oncology
IRB Code: 110771
Study Title: AAML1031, A Phase III Randomized Trial for Patients with de novo AML using Bortezomib (IND# 58443, NSC# 681239) and Sorafenib (BAY 43-9006, IND#69896, NSC# 724772) for Patients with High Allelic Ratio FLT3/ITD
Category: Oncology
IRB Code: 611105
Study Title: ABTR01B1, A Children's Oncology Group Protocol for Collecting and Banking Pediatric Research Specimens Including Rare Pediatric Tumors
Category: Oncology
IRB Code: 110554T
Study Title: ACCL0933 A Randomized Open-Label Trial of Caspofungin versus Fluconazole to Prevent Invasive Fungal Infections in Children Undergoing Chemotherapy for Acute Myeloid Leukemia (AML)
Category: Oncology
IRB Code: 70436
Study Title: ACNS0332: Efficacy of Carboplatin Administered Concomitantly With Radiation and Isotretinoin as a Pro-Apoptotic Agent in Other Than Average Risk Medulloblastoma/PNET Patients
Category: Oncology
IRB Code: 90215
Study Title: ACNS0333, Treatment of Atypical Teratoid/Rhabdoid Tumors of the Central Nervous System with Surgery, Intensive Chemotherapy, and 3-D Conformal Radiation
Category: Oncology
IRB Code: 70861
Study Title: ACNS0334: A Phase III Randomized Trial for the Treatment of Newly Diagnosed Supratentorial PNET and High Risk Medulloblastoma in Children < 36 Months Old with Intensive Induction Chemotherapy with Methotrexate Followed by Consolidation with Stem Cell Rescue vs. the Same Therapy Without Methotrexate (ACNS0334)
Category: Oncology
IRB Code: 1012123
Study Title: ACNS0821 Temozolomide with Irinotecan versus Temozolomide, Irinotecan plus Bevacizumab (NSC# 704865, BB-IND# 7921) for Recurrent/Refractory Medulloblastoma/CNS PNET of Childhood, A COG Randomized Phase II Screening Trial
Category: Oncology
IRB Code: 1011118
Study Title: ACNS0822 A Randomized Phase II/III Study of Vorinostat (IND# 71976) and Local Irradiation OR Temozolomide and Local Irradiation OR Bevacizumab and Local Irradiation Followed by Maintenance Bevacizumab (IND # 7921) and Temozolomide in Newly Diagnosed High Grade Glioma
Category: Oncology
IRB Code: 100544
Study Title: ACNS0831 Phase III Randomized Trial of Post-Radiation Chemotherapy in Patients with Newly Diagnosed Ependymoma Ages 1 to 21 years
Category: Oncology
IRB Code: 100985T
Study Title: ACNS0927 A Phase 1/2 Study of Suberoylanilide Hydroxamic Acid (SAHA, Vorinostat) and Local Irradiation, Followed by Maintenance SAHA in Children with Newly Diagnosed Diffuse Intrinsic Pontine Gliomas (DIPG)
Category: Oncology
IRB Code: 120439
Study Title: ACNS1021, A Phase II Study of Sunitinib (NSC# 736511, IND# 74019) in Recurrent, Refractory or Progressive High Grade Glioma and Ependymoma Tumors in Pediatric and Young Adult Patients
Category: Oncology
IRB Code: 120659
Study Title: ACNS1022, A Phase II Randomized Trial of Lenalidomide (NSC # 703813, IND # 70116) in Pediatric Patients with Recurrent, Refractory or Progressive Juvenile Pilocytic Astrocytomas and Optic Pathway Gliomas
Category: Oncology
IRB Code: 120660
Study Title: ACNS1123 Phase 2 Trial of Response-Based Radiation Therapy for Patients with Localized Central Nervous System Germ Cell Tumors (CNS GCT)
Category: Oncology
IRB Code: 100329
Study Title: Addition of Ginger to Control Difficult Chemotherapy-Induced Nausea and/or Vomiting in Adolescents - A Questionnaire
Category: Oncology
IRB Code: 100104
Study Title: Adolescents and Young Adults with Cancer and their Parents: The Influence of Dyadic Interactions on Adjustment
Category: Oncology
IRB Code: 90659
Study Title: ADVL0816 A PHASE I STUDY OF OBATOCLAX (PAN ANTI-APOPTOTIC BCL-2 FAMILY SMALL MOLECULE INHIBITOR), IN COMBINATION WITH VINCRISTINE/DOXORUBICIN/DEXRAZOXANE, IN CHILDREN WITH RELAPSED/REFRACTORY SOLID TUMORS OR LEUKEMIA
Category: Oncology
IRB Code: 100218
Study Title: ADVL0911 A PHASE 1 DOSE ESCALATION STUDY OF SENECA VALLEY VIRUS (NTX-010), A REPLICATION-COMPETENT PICORNAVIRUS, IN RELAPSED/REFRACTORY PEDIATRIC PATIENTS WITH NEUROBLASTOMA, RHABDOMYOSARCOMA, OR RARE TUMORS WITH NEUROENDOCRINE FEATURES
Category: Oncology
IRB Code: 90997
Study Title: ADVL0912, A Phase 1/2 Study of PF-02341066, an Oral Small Molecule Inhibitor of Anaplastic Lymphoma Kinase (ALK) and C-Met, in Children with Relapsed/Refractory Solid Tumors and Anaplastic Large Cell Lymphoma
Category: Oncology
IRB Code: 100657
Study Title: ADVL0918, A Phase 1 Study of Temsirolimus in Combination with Irinotecan and Temozolomide in Children, Adolescents, and Young Adults with Relapsed or Refractory Solid Tumors
Category: Oncology
IRB Code: 110227
Study Title: ADVL0921 A Phase II Study of MLN8237 (IND# 102984), a Selective Aurora A Kinase Inhibitor in Children with Recurrent/Refractory Solid Tumors and Leukemias
Category: Oncology
IRB Code: 100991
Study Title: ADVL1011 A PHASE 1 STUDY OF JAK INHIBITION (INCB018424) IN CHILDREN WITH RELAPSED OR REFRACTORY SOLID TUMORS, LEUKEMIAS, AND MYELOPROLIFERATIVE NEOPLASMS
Category: Oncology
IRB Code: 1012128
Study Title: ADVL1014, A Phase I dose escalation study of REOLYSIN, a replication competent reovirus, in pediatric patients with relapsed or refractory solid tumors
Category: Oncology
IRB Code: 110553
Study Title: ADVL1112 A PHASE 1 STUDY OF IMETELSTAT, A TELOMERASE INHIBITOR, IN CHILDREN WITH REFRACTORY OR RECURRENT SOLID TUMORS AND LYMPHOMAS
Category: Oncology
IRB Code: 110984
Study Title: ADVL1114, A Phase 1 Study of Temsirolimus (CCI-779, IND#61010) in Combination with Intensive Re-induction Therapy for Children with Relapsed Acute Lymphoblastic Leukemia and Non-Hodgkin Lymphoma
Category: Oncology
IRB Code: 120330
Study Title: ADVL1115, A Phase 1 Study of AMG 386 (IND# 114215), an Angiopoietin Neutralizing Peptibody, in Children with Relapsed or Refractory Solid Tumors, including CNS Tumors
Category: Oncology
IRB Code: 120120
Study Title: ADVL1121, A Phase II Study of the Raf Kinase and Receptor Tyrosine Kinase Inhibitor Sorafenib (IND# 69896) in Children and Young Adults with Relapsed/Refractory Rhabdomyosarcoma, Wilms Tumor, Hepatocellular Carcinoma, and Papillary Thyroid Carcinoma
Category: Oncology
IRB Code: 120664
Study Title: ADVL1221 A Phase II Study of Cixutumumab (IMC-A12; IND# 100947) in Combination with Temsirolimus (IND# 61010) in Pediatric Patients with Recurrent or Refractory Solid Tumors
Category: Oncology
IRB Code: 80404
Study Title: AEWS07B1 A Children?s Oncology Group Protocol for Collecting and Banking Ewing Sarcoma Specimens (At Initial Diagnosis)
Category: Oncology
IRB Code: 1012122
Study Title: AEWS1031 A Phase III Randomized Trial of Adding Vincristine-topotecan-cyclophosphamide to Standard Chemotherapy in Initial Treatment of Non-metastatic Ewing Sarcoma
Category: Oncology
IRB Code: 911110
Study Title: AHEP0731 Treatment of Children with All Stages of Hepatoblastoma
Category: Oncology
IRB Code: 70106
Study Title: AHOD04B1, Hodgkin Disease (HD) Banking Study.
Category: Oncology
IRB Code: 811127
Study Title: ALTE05N1 Umbrella Long-Term Follow-up Protocol
Category: Oncology
IRB Code: 90216
Study Title: ALTE07C1, Neuropsychological, Social, Emotional and Behavioral Outcomes in Children with Cancer
Category: Oncology
IRB Code: 120661
Study Title: An Open Label, Single Arm, Multi-center Pharmacokinetic Study of Intravenous Erwinaze (asparaginase Erwinia chrysanthemi) Following Allergy to Native E. Coli Asparaginase (Elspar or Kidrolase), Pegaspargase (Oncaspar) or Calaspargase pegol (EZN-2285) in Children, Adolescents and Young Adults with Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma
Category: Oncology
IRB Code: 70968
Study Title: An Open-Label Treatment Protocol for the Use of Voraxaze as Adjunctive Treatment for Patients Experiencing or at Risk of Methotrexate Toxicity.
Category: Oncology
IRB Code: 120544
Study Title: An open-label, cross-over, pharmacokinetic study to assess the safety and pharmacokinetics of transdermal granisetron (Sancuso patch) and IV granisetron in a pediatric oncology population (aged 13 to 17 years).
Category: Oncology
IRB Code: 80403
Study Title: AOST06B1 A Children?s Oncology Group Protocol for Collecting and Banking Osteosarcoma Specimens
Category: Oncology
IRB Code: 100543
Study Title: ARAR0332 Treatment of Adrenocortical Tumors with Surgery plus Lymph Node Dissection and Multiagent Chemotherapy
Category: Oncology
IRB Code: 60536
Study Title: AREN03B2: Renal Tumors Classification, Biology, and Banking Study
Category: Oncology
IRB Code: 70544
Study Title: AREN0533 Treatment of Newly Diagnosed Higher Risk Favorable Histology Wilms Tumors
Category: Oncology
IRB Code: 90994
Study Title: AREN0534 Treatment for Patients with Bilateral, Multicentric, or Bilaterally-Predisposed Unilateral Wilms Tumor
Category: Oncology
IRB Code: 80562
Study Title: ARST0332 Risk-Based Treatment for Pediatric Non-Rhabdomyosarcoma Soft Tissue Sarcomas (NRSTS) in Patients Under 30 Years of Age
Category: Oncology
IRB Code: 100215
Study Title: ARST08P1: A Pilot Study to Evaluate Novel Agents (Temozolomide and Cixutumumab [IMC-A12, Anti-IGF-IR Monoclonal Antibody, IND #100947, NSC # 742460]) in Combination with Intensive Multi-Agent Interval Compressed Therapy for Patients with High-Risk Rhabdomyosarcoma
Category: Oncology
IRB Code: 1010112
Study Title: ARST0921 A Randomized Phase II Trial of Bevacizumab (IND# 7921, Avastin) and Temsirolimus (IND# 61010, Torisel) in Combination with Intravenous Vinorelbine and Cyclophosphamide in Patients with Recurrent/Refractory Rhabdomyosarcoma
Category: Oncology
IRB Code: 120323
Study Title: BMS CA180-372 (COG AALL1122) A Phase 2 Multi-Center Historically-Controlled Study of Dasatinib Added to Standard Chemotherapy in Pediatric Patients with Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ ALL)
Category: Oncology
IRB Code: 100882
Study Title: California Childhood Leukemia Study
Category: Oncology
IRB Code: 110664
Study Title: Childhood Cancer Survivor Study
Category: Oncology
IRB Code: 80210
Study Title: COG ASCT0431 A Randomized Trial of Sirolimus-Based Graft versus Host Disease Prophylaxis after Hematopeietic Stem Cell Transplantation in Relapsed ALL.
Category: Oncology
IRB Code: 60650
Study Title: COG: AADM0211: Eligibility Screening Tool for COG Developmental Therapeutics/Phase I Consortium Clinical Research Protocols
Category: Oncology
IRB Code: 40212
Study Title: COG: AALL0232: High Risk B-Percursor Acute Lymphoblastic Leukemia
Category: Oncology
IRB Code: 61088
Study Title: COG: AALL05B1: A Children's Oncology Group Protocol for Collecting and Banking Relapsed Acute Lymphoblastic Leukemia Research Specimens
Category: Oncology
IRB Code: 41171
Study Title: COG: ACNS02B3: A Children's Oncology Group Protocol for Collecting and Banking Pediatric Brain Tumor Research Specimens
Category: Oncology
IRB Code: 51103
Study Title: COG: ADVL04P2: A Phase I/II Pilot Study of Chemoimmunotherapy with Epratuzamab for Children with Refractory CD22-Positive Acute Lymphoblastic Leukemia
Category: Oncology
IRB Code: 01-020
Study Title: COG: ANBL0032: Phase III Randomized Study of Chimeric Antibody 14.18 (Ch14.18) in High Risk Neuroblastoma Following Myeloblative Therapy and Autologous Stem Cell Rescue
Category: Oncology
IRB Code: 01-008IHT
Study Title: COG: ANBL00B1: Neuroblastoma Biology Study
Category: Oncology
IRB Code: 70101
Study Title: COG: AREN0321: Treatment of High Risk Renal Tumors
Category: Oncology
IRB Code: 70102
Study Title: COG: AREN0532: Treatment for Very Low and Standard Risk Favorable Histology Wilms Tumor
Category: Oncology
IRB Code: 70215
Study Title: COG: ARST0531: Randomized Study of Vincristine, Dactinomycin and Cyclophosphamide (VAC) versus VAC Alternating with Vincristine and Irinotecan (VI) for Patients with Intermediate-Risk Rhabdomyosarcoma (RMS).
Category: Oncology
IRB Code: 00-017T
Study Title: COG: D9902: A COG Soft Tissue Sarcoma Diagnosis, Biology and Banking Protocol
Category: Oncology
IRB Code: 96-009
Study Title: COG: L4941: National Wilms Tumor Late Effects Study
Category: Oncology
IRB Code: 100666
Study Title: CPT-SIOP-2009, Intercontinental Multidisciplinary Registry and Treatment Optimization study for Patients with Choroid Plexus Tumors
Category: Oncology
IRB Code: 90998
Study Title: Defibrotide for Patients with Hepatic Veno-occlusive Disease (VOD): A Treatment IND Study (Under CFR 312.34)
Category: Oncology
IRB Code: 1111100
Study Title: Expanded Access of Prochymal (Ex-Vivo Cultured Adult Human Mesenchymal Stem Cells) Infusion for the Treatment of Pediatric Patients Who Have Failed to Respond to Steroid Treatment for Acute GVHD
Category: Oncology
IRB Code: 080219T
Study Title: Liposomal Muramyl Tripeptide Phosphatidyl Ethanolamine (L-MTP-PE): Compassionate Access for High Risk Osteosarcoma
Category: Oncology
IRB Code: 111096
Study Title: Mathematical Modeling of Mutant p53 in a Li-Fraumeni Syndrome Population
Category: Oncology
IRB Code: 80776
Study Title: NIH: Oncofertility Consortium: Fertility Preservation in Women and Girls with Cancer
Category: Oncology
IRB Code: 111095
Study Title: NMTRC 001: A Feasibility Trial using Molecular-Guided Therapy for the Treatment of Patients with Refractory or Recurrent Neuroblastoma
Category: Oncology
IRB Code: 100324
Study Title: Pilot Project Grant: To Study FGFR3 Expression and Mutations in Pediatric Cancers
Category: Oncology
IRB Code: 120543
Study Title: Pilot Project: Assessing the Feasibility of Applying Molecular Profiling Data to Clinical Decision Making in Childhood, Adolescent, and Young Adult Cancers
Category: Oncology
IRB Code: 120555
Study Title: Pilot Project: Gastrointestinal Microbe Population Changes in Newly Diagnosed Pediatric Pre-B Acute Lymphoblastic Leukemia Patients
Category: Oncology
IRB Code: 111199
Study Title: Pilot Project: Molecular Profiles of Refractory and Recurrent Childhood, Adolescent, and Young Adult Cancers
Category: Oncology
IRB Code: 111097
Study Title: Prospective Data Collection for Patients with Acute Lymphoblastic and Acute Myeloid Leukemia (A companion protocol to Pilot Project: Molecular Profiles of Refractory and Recurrent Childhood, Adolescent, and Young Adult Cancers)
Category: Oncology
IRB Code: 80209
Study Title: Protocol for the Enrollment on the Official COG Registry, the Childhood Cancer Research Network (CCRN)
Category: Oncology
IRB Code: 02-022IH
Study Title: The National Marrow Donor Program? and Center for International Blood and Marrow Transplant Research (CIBMTR) Protocol for a Research Sample Repository for Allogeneic Hematopoietic Stem Cell Transplantation
Category: Oncology
IRB Code: 02-023IH
Study Title: The National Marrow Donor Program? and Center for International Blood and Marrow Transplant Research (CIBMTR): A Research Database for Hematopoietic Stem Cell Transplantation
Category: Oncology
IRB Code: 1010108
Study Title: Therapeutic Potential of TOR Pathway Inhibitors in Pediatric ALL
Category: Oncology
IRB Code: 90996
Study Title: Yondelis? (trabectedin) Single Patient Compassionate Use / Expanded Access in Soft Tissue Sarcoma

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