Leading-edge Children’s Research
CHOC offers access to cutting-edge pediatric research and clinical trials that can't be found anywhere else.
CHOC Research - Go Beyond

CHOC Research Institute

Terence Sanger, Chief Scientific Officer at CHOC, speaks to the importance of research at a children’s hospital.

We conduct research directly with children and adolescents in a facility devoted exclusively to the care, quality of life, rights and safety of children of all ages.

At CHOC, we know that research saves lives. That’s why our Research Institute has more than 500 research studies in more than 30 specialties to provide your child with access to leading-edge treatments. Our scientists translate the latest advances in molecular profiling, including whole genome sequencing, to meet the individual needs of our patients at every stage of their young lives —from infancy through adolescence.


Clinical Trials

Clinical Trials

At CHOC, we are dedicated to providing patients the very latest breakthrough treatments available to children, adolescents and young adults. Our efforts bring hope to patients with rare conditions, or conditions not responding to traditional treatments.

About the CHOC Research Institute

The CHOC Research Institute was formally established in 2003, after years of active participation in pediatric clinical research. Today, the Research Institute supports more than 350 active human-subject research studies across nearly all of our pediatric subspecialty areas.

The Institute’s Sponsored Projects and Research Compliance offices administer and oversee federal NIH, California State CIRM, private foundation and donor funding in support of translational and clinical child health research.

The Research Institute also has a formal affiliation with UC Irvine, a collaboration that brings advanced treatment to patients. Through the partnership, additional grants have been awarded to both institutions, and CHOC researchers have access to valuable University resources, like the Beckman Laser Institute, in an effort to bring breakthrough therapies and cures to pediatric patients.

Research Professionals

The Research Institute is committed to delivering comprehensive service, from pre-award assistance to post-award management. We make every effort to accommodate individual researcher's needs and schedules within the resources of our office, and we act as an advocate for the faculty and the university in the research process.

Institutional Review Boards
CHOC currently has two Institutional Review Boards
Research Administration
CHOC's Research Administration office is a valuable resource for the CHOC community, providing expertise and highly specialized service in the important area of research management.
Proposal Preparation
Information you need for proposal preparation.

Stories of Innovative Pediatric Research

baby lays in crib in CHOC NICU

CHOC’s study published in the Pediatrics journal finds that though COVID-19 infections in newborns are rare, they may cause severe disease.

CHOC logo  CHOC Provider Blog


The Fragile X Clinic at CHOC will be devoted to the diagnosis, treatment, and study of the rare genetic condition of Fragile X syndrome.

CHOC logo  CHOC Provider Blog

Graphic depiction of DNA

CHOC selected as West Coast site for gene therapy clinical trial for patients 8 years and older with Glycogen Storage Disease type 1a.

CHOC logo  CHOC Provider Blog

Doctor speaks to young girl

New CHOC study integrating mental health into primary care seeks patients to receive cognitive therapy and/or medication.

CHOC logo  CHOC Provider Blog

Emergency sign at CHOC's emergency department in Orange, CA

Dr. Raina Paul is making strides in quality-improvement science to better pediatric sepsis at CHOC’s emergency department.

CHOC logo  CHOC Provider Blog

Dr. Terri Inder standing beside a NICU incubator

CHOC is thrilled to introduce neonatologist and child neurologist Dr. Terrie Inder to advance outcomes of neonatal-perinatal medicine.

CHOC logo  CHOC Provider Blog

dog laying on floor

With hundreds kids being treated for dog bites each year at CHOC, experts discuss why dogs bite kids and how to prevent injury.

CHOC logo  CHOC Health

Boy smiles in front of inflatable bounce house

A study by the CHOC Research Institute shows a rise in injuries caused by bounce houses. Learn how to keep your kids safe in bounce houses.

CHOC logo  CHOC Health

Naomi and twin sister Natalie at Disneyland with Pluto

CHOC doctors secured a one-time compassionate use FDA approval to use a cutting-edge device to help remove Naomi’s tumor and save her leg.

CHOC logo  CHOC Health

Discover the latest advances in pediatric medicine, research and innovation.

Contact Us


Location: CHOC Research Building – 4th Floor

Phone: 714-509-4341 | Fax: 714-509-4318