Nael Amzajerdi, MD, Pediatric Pathology

Nael Amzajerdi, MD, Pediatric Pathology

  • Ali Nael Amzajerdi MD
  • Appointments:
  • Specialty: Pathology
  • Board Certified: Anatomic Pathology, Clinical Pathology, Hematopathology, Pediatric Pathology
  • Additional Languages: Farsi

Dr. Nael is a board-certified pediatric pathologist who identifies diseases in kids and adolescents at CHOC. He serves as Assistant Medical Director of CHOC Pathology Department. He is an Associate Professor at the University of California Irvine Medical School. Dr. Nael received his Medical Degree from Shiraz University of Medical Sciences in Iran. He completed his Anatomic Pathology and Clinical Pathology residency at the University of California Irvine Medical Center. Dr. Nael completed his Pediatric Pathology Fellowship at Children’s Hospital Los Angeles (CHLA) and completed his Hematopathology Fellowship at University of Southern California (USC) in Los Angeles, CA. Dr. Nael oversees training for CHOC Pathology residents and fellows.

Ali Nael Amzajerdi MD is on staff at CHOC Hospital in Orange .


CHOC Pathology
1201 W La Veta Ave
Orange, CA 92868
phone: 714-509-9012
fax: 714-509-9027

Orange County Pathology Medical Group
805 W. La Veta Ave, #104
Orange, CA 92868
Phone: 714-288-4044
Fax: 714-288-4042


  • Medical School
    Doctor of Medicine
    Shiraz University of Medical Sciences, Iran
  • Residency
    Anatomic Pathology & Clinical Pathology

    University of California Irvine Medical Center, Orange, CA
  • Fellowships

    University of Southern California (USC) Medical Center, Los Angeles, CA
    Pediatric Pathology
    Children’s Hospital Los Angeles (CHLA), Los Angeles, CA

Special Interests

  • Gastrointestinal Pathology
  • Soft Tissue & Bone Pathology

Administrative Appointment

  • Director of Anatomic Pathology
    Department of Pathology, CHOC
  • Associate Medical Director
    Department of Pathology, CHOC

Academic Title

  • Assistant Professor
    Department of Pathology, UC Irvine School of Medicine, Irvine, California

Professional Organization

  • UC Irvine University Physicians & Surgeons, Affiliate

Awards and Acknowledgment

2024: Orange County Physician of Excellence.

2020: 2020 American Society for Clinical Pathology (ASCP) 40 Under Forty Honorees. Being recognized among 40 high-achieving pathologists, pathology residents, and medical laboratory professionals under age 40 in the nation.

2018: Pathologist-in-Training Travel Award presented by United States and Canadian Academy of Pathology (USCAP) Foundation.

2017: Intersociety Council for Pathology Information (ICPI) Travel Stipend Award presented by Society for Pediatric Pathology.

2016: Grant: Identification of Clinically Actionable Genomic Lesions in Pediatric Diffuse Large B-cell Lymphoma, $38,800 SC CTSI Pilot Funding Program – Award, UL1TR001855.
Warren L. Bostick Award for Excellence in Residency Teaching, UCI Department of Pathology and Laboratory Medicine.
Edward R. Arquilla Award for Excellence in Research, UCI Department of Pathology and Laboratory Medicine.

2015: Acknowledgement by authors for editorial review; David M Parham et al, Pediatric Malignancies: Pathology and Imaging, soft tissue sarcoma chapter, Springer 2015: 19-68.

2014: American Society for Clinical Pathology (ASCP) Case Report honorarium.


Dr. Nael’s complete list of publications can be found here:

Villablanca JP, Nael K, Habibi R, Nael A, Laub G, Finn JP. 3 T contrast-enhanced magnetic resonance angiography for evaluation of the intracranial arteries: comparison with time-of-flight magnetic resonance angiography and multislice computed tomography angiography. Invest Radiol. 2006 Nov;41(11):799-805.

Nael K, Villablanca JP, Saleh R, Pope W, Nael A, Laub G, Finn JP. Contrast-enhanced MR angiography at 3T in the evaluation of intracranial aneurysms: a comparison with time-of-flight MR angiography. AJNR Am J Neuroradiol. Nov-Dec 2006;27(10):2118-21.

Nael K, Krishnam M, Nael A, Ton A, Ruehm SG, Finn JP. Peripheral Contrast-Enhanced MR Angiography at 3.0T: Improved spatial resolution and low dose contrast: Initial clinical experience. Eur Radiol. 2008 Dec;18(12):2893-900.

Guo D, Reinitz F, Youssef M, Hong C, Nathanson D, Akhavan D, Kuga D, Amzajerdi AN, et al. An LXR Agonist Promotes GBM Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway. Cancer Discovery. 2011 Oct;1(5):442-56.

Tanaka K, Babic I, Nathanson D, Akhavan D, Guo D, Gini B, Dang J, Zhu S, Yang H, de Jesus J, Amzajerdi AN, et al. Oncogenic EGFR Signaling Activates an mTORC2-NF-κB Pathway That Promotes Chemotherapy Resistance. Cancer Discovery. 2011 Nov;1(6):524-38.

Iwanami A, Gini B, Zanca C, Matsutani T, Assuncao A, Nael A, et al. PML mediates glioblastoma resistance to mammalian target of rapamycin (mTOR)-targeted therapies. Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):4339-44.

Akhavan D, Pourzia AL, Nourian AA, Williams KJ, Nathanson D, Babic I, Villa GR, Tanaka K, Nael A, et al. De-Repression of PDGFRβ Transcription Promotes Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in Glioblastoma Patients. Cancer Discov. 2013 May;3(5):534-47.

Nael A, Siaghani P, Wu WW, Nael K, Shane L and Romansky SG. Metastatic malignant ectomesenchymoma initially presenting as a pelvic mass: report of a case and review of literature. Case Rep in Pediatr. 2014;2014:792925.

Wu WW, Chu J, Nael A, Rezk S, Romansky SG and Shane L. Thyroid-like follicular carcinoma of the kidney in a young patient with history of pediatric acute lymphoblastic leukemia. Case Rep Pathol. 2014;2014:313974.

Nael A, Wu ML, Nagesh Rao P, Rezk S, Zhao X. Extranodal Marginal Zone Lymphoma Presenting within the Meckel’s Diverticulum as Diverticulitis, a Case Report. Case Rep Pathol. 2014;2014:374814.

Nael A, Johnston A, Dacosta-lyer M, Ouyang Y, Deshmukh S, Lambrecht N. An Intimal Cardiac Sarcoma with overexpression of MDM2, First Presented as Intestinal Obstruction, a case report and review of literature. ASCP Case Reports. 2014; SP1404. Chicago, Illinois: American Society for Clinical Pathology

Nael A, Siaghani PJ, Romansky SG, Shane L. Idiopathic Infantile Arterial Calcification: A Possible Cause of Refractory Cardio-Pulmonary Failure in Infancy. Case Rep Pathol. 2014;2014:189850.

Nael A, Walavalkar V, Wu WW, Nael K, Rezk S, Zhao X. CD4-positive T-cell Primary Central Nervous System Lymphoma in an HIV Positive Patient. Am J Clin Pathol. 2016 Feb;145(2):258-265.

Nael A, Wu WW, Shane L, Rao N and Zwerdling T. Primitive spindle cell neoplasm of ileum with extensive heterotopic cartilage, presenting as acute abdomen in a 6-day-old neonate. Pediatr Dev Pathol. Jul-Aug 2016;19(4):338-44.

Vaziri Fard E, Nael A, Lin F, Nangia C, Wang BY. Primary osteosarcoma of the parotid gland: A case report and literature review. Case Reports in Clinical Pathology. 2016 Sep; 3(4):61-65.

Sarkissian SV, Amzajerdi AN, Rezk SA. Hemophagocytic lymphohistiocytosis in a patient with extranodal natural killer lymphoma, nasal type, complicated by bone marrow and central nervous system involvement. The New Armenian Medical Journal. 2017 June;11(2):10-15.

Moke D, Thomas SM, Hiemenz MC, Nael A, Wang K, Shillingford N, Biegel JA and Mascarenhas L. Three Synchronous malignancies in a patient with DICER1 Syndrome. Eur J Cancer. 2018 Apr;93:140-143.

Farrell D, Nael A, Law T, Zhao X, Weiss LM, Rezk SA. Epstein–Barr virus (EBV) incidental expression in bone marrow cells, a study of 230 consecutive bone marrow biopsy samples. Hum Pathol. 2019 Jun;88:60-65.

Nael A, Wu W, Siddiqi I, Zhao X, Kahlon K and Rezk AS. Epstein-Barr Virus Association with Plasma Cell Neoplasms. Histol Histopathol. 2019 Jun;34(6):655-662.

Glavis-Bloom J, Nahl D, Rubin EM, Nael A, Dao T. Congenital neuroglial choristoma of the foot. Radiol Case Rep. 2019 Apr;14(6):718-722.

Hermel DJ, Nael A, Lu YT, Kim J, Brynes RK, Vergara-Lluri M, Akhtari M. Gelatinous bone marrow transformation and emergence of clonal Philadelphia-negative cytogenetic abnormalities with excess blasts in a patient with chronic myeloid leukemia treated with dasatinib. Anticancer drugs. 2019 Apr;30(4):416-421.

Chang MR, Chon AH, Baskin J, Nael A, Chmait RH. Case 1: Cardiac Arrest in a 2-month-old Boy with a Prenatal Course Complicated by Alloimmunization. Pediatr Rev. 2019 May;40(5):243-246.

Martynova A, Nael A, O Neill C, Ramsingh G, Merchant A, Yaghmour B, Yaghmour G. Aggressive systemic mastocytosis: midostaurin is safe, feasible and associated with durable response post-haploidentical allogeneic stem cell transplant. Br J Haematol. 2019 Sep;186(5):e139-e141.

Shestakova A, Rezk S, Ghasemizadeh D, Nael A, Zhao X. High-grade B-cell Lymphoma with MYC and BCL2 Rearrangement Arising from Follicular Lymphoma: Presentation as a Large Peripancreatic Mass. Diagnostics (Basel). 2020 Mar 14;10(3):157.

Johnston RC, Faulkner M, Carpenter PM, Nael A, Haydel D, Sandman CA, Wing DA, Davis EP. Associations Between Placental Corticotropin-Releasing Hormone, Maternal Cortisol, and Birth Outcomes, Based on Placental Histopathology. Reprod Sci. 2020 Sep;27(9):1803-1811.

Shestakova A, Nael A, Nora V, Rezk S and Zhao X. Automated leukocyte parameters are useful in the assessment of myelodysplastic syndromes. Cytometry B Clin Cytom. 2021 May;100(3):299-311

Morales S, Nael A, Buchbinder D. Copper Deficiency and Cytopenias. J Pediatr Hematol Oncol. 2021 Mar;43(2):68-69.

Guo W, Farzaneh T, Lee W, Nael A, Li X, Chandan VS. A Limited Panel of INSM1 and LEF1 Immunostains Accurately Distinguishes Between Pancreatic Neuroendocrine Tumor and Solid Pseudopapillary Neoplasm. Pathol Res Pract. 2021 Jul;223:153462.

Lee W, HaDuong J, Sassoon A, Dao T, Nael A. A Liver Transplant for Local Control in a Pediatric Patient with Metastatic TFE3-Associated Perivascular Epithelioid Cell Tumor (PEComa) to the Liver. Case Rep Pathol. 2021 Oct 5;2021:3924565.

Buchbinder D, Hsieh L, Frediani J, Zadeh N, Nael A. MDS and MIRAGE. J Pediatr Hematol Oncol. 2022 Oct 1;44(7):421-422.

Wu S, Kim A, Gu Y, Martinez D, Zocchi L, Chen C, Lopez J, Salcido K, Singh S, Wu J, Nael A, Benavente C. UHRF1 overexpression promotes osteosarcoma metastasis through altered exosome production and AMPK/SEMA3E suppression. Oncogenesis. 2022 Sep 6;11(1):51.

Xu J, Suzuki S, Chrislip J, Nael A, Loudon W. Embolization of a third ventricular choroid plexus papilloma: illustrative case. J Neurosurg Case Lessons. 2022 Jan 31;3(5): CASE21516.

Kumar N, Nael A, Sato M, Crawford JR. Delayed diagnosis of diffuse leptomeningeal glioneuronal tumour in a young child presenting with communicating hydrocephalus. BMJ Case Rep. 2022 Dec 19;15(12):e253238.

Ralbovsky A, Reyna T, Kabeer M, Nael A, Yang C. Not All that Strictures Is IBD: Gastric Heterotopia Leading to Perforation and Small Bowel Obstruction Mimicking IBD. JPGN Rep. 2022 Feb 4;3(1):e106.

Chou S, Nael A, Crawford JR, Sato M. A rare case of pediatric MN1-altered astroblastoma with concomitant ATM germline mutation. Pediatr Blood Cancer. 2023 Jun 30:e30502.