Leading-edge Children’s Research
CHOC offers access to cutting-edge pediatric research and clinical trials that can't be found anywhere else.
CHOC Research - Go Beyond

CHOC Research Institute

Terence Sanger, Chief Scientific Officer at CHOC, speaks to the importance of research at a children’s hospital.

We conduct research directly with children and adolescents in a facility devoted exclusively to the care, quality of life, rights and safety of children of all ages.

At CHOC, we know that research saves lives. That’s why our Research Institute has more than 500 research studies in more than 30 specialties to provide your child with access to leading-edge treatments. Our scientists translate the latest advances in molecular profiling, including whole genome sequencing, to meet the individual needs of our patients at every stage of their young lives —from infancy through adolescence.


Clinical Trials

Clinical Trials

At CHOC, we are dedicated to providing patients the very latest breakthrough treatments available to children, adolescents and young adults. Our efforts bring hope to patients with rare conditions, or conditions not responding to traditional treatments.

About the CHOC Research Institute

The CHOC Research Institute was formally established in 2003, after years of active participation in pediatric clinical research. Today, the Research Institute supports more than 350 active human-subject research studies across nearly all of our pediatric subspecialty areas.

The Institute’s Sponsored Projects and Research Compliance offices administer and oversee federal NIH, California State CIRM, private foundation and donor funding in support of translational and clinical child health research.

The Research Institute also has a formal affiliation with UC Irvine, a collaboration that brings advanced treatment to patients. Through the partnership, additional grants have been awarded to both institutions, and CHOC researchers have access to valuable University resources, like the Beckman Laser Institute, in an effort to bring breakthrough therapies and cures to pediatric patients.

Research Professionals

The Research Institute is committed to delivering comprehensive service, from pre-award assistance to post-award management. We make every effort to accommodate individual researcher's needs and schedules within the resources of our office, and we act as an advocate for the faculty and the university in the research process.

Institutional Review Boards
CHOC currently has two Institutional Review Boards
Research Administration
CHOC's Research Administration office is a valuable resource for the CHOC community, providing expertise and highly specialized service in the important area of research management.
Proposal Preparation
Information you need for proposal preparation.

Stories of Innovative Pediatric Research

dog laying on floor

With hundreds kids being treated for dog bites each year at CHOC, experts discuss why dogs bite kids and how to prevent injury.

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doctor holds digital pair of lungs

The national study of over 60,000, researchers concluded that asthma symptoms worsened in the six months following a COVID-19 infection.

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Boy with cardboard wings looks at toy airplane

At the inaugural CHOC/UCI Rare Disease Conference, providers discussed plans for extended research, collaboration and treatment strategies.

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Boy smiles in front of inflatable bounce house

A study by the CHOC Research Institute shows a rise in injuries caused by bounce houses. Learn how to keep your kids safe in bounce houses.

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bounce house

A CHOC-led study on the frequency of bounce house injuries reveals the safety concerns and the need for prevention tactics.

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baby in crib in NICU

A partnership between CHOC and Masimo has developed technology to noninvasively monitor blood oxygen and hemoglobin levels in newborns.

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Graphic representation of molecules

CHOC helps develop innovative treatment protocols for PTCL and NK/T-cell lymphoma, which are now available for patients.

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dad had daughter on his shoulders and they look into the bright sky

The Inaugural CHOC and UCI Rare Disease Symposium & Family Conference will take place on Friday, March 11, 2022, from 10:30 a.m. to 3 p.m.

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Naomi and twin sister Natalie at Disneyland with Pluto

CHOC doctors secured a one-time compassionate use FDA approval to use a cutting-edge device to help remove Naomi’s tumor and save her leg.

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Visit CHOC Provider Connection for more research and innovation articles.

Contact Us


Location: CHOC Research Building – 4th Floor

Phone: 714-509-4341 | Fax: 714-509-4318

CHOC Clinical Care and Research Attracts Patients Worldwide

The McGregor family of Blackfalds, Alberta, Canada found CHOC while searching for treatment alternatives for their 11-year-old daughter, Katharina (Katha). Katha has Niemann-Pick disease Type C (NP-C), a rare genetic disease that causes cholesterol to accumulate in the brain, lungs, liver and spleen, leading to deterioration and early death.

Since March 2016, Katha and her mother have traveled from Canada to CHOC every other week to participate in a yearlong clinical trial. While the travel is challenging, McGregor says it is definitely worthwhile. Read Katha’s story.