Dr. Sirisha Perugu, Neonatology

Sirisha Perugu, MD, is board certified in general pediatrics and neonatal-perinatal medicine. She completed her residency training at William Beaumont Hospital, Royal Oak, Michigan. She served her fellowship in Neonatology at Harbor-UCLA Medical Center, Torrance, California and CHOC Children’s, Orange, California. She attended medical school at Gandhi Medical College, Hyderabad, India.

Dr. Perugu’s clinical interest is neonatal cardiovascular physiology and palliative care. She is a member of the American Academy of Pediatrics (AAP). She has a strong commitment to excellence. Her favorite aspect of the physician-patient relationship is being an advocate for the patient’s best interest and supporting families.

Dr. Perugu is passionate about taking care of infants with complex illnesses and their families. She has been instrumental in bringing CHOC’s supportive care program to the neonatal intensive care unit (NICU) and other areas of the hospital. “I am privileged to help your family and hope that we can support your vision of dignified and thoughtful care,” she says. Families can also call on Dr. Perugu if a baby has been diagnosed with a serious condition during prenatal testing. “Prenatal counseling is a precious first step in every family’s journey and we will partner every time your family needs help with plans and communication,” she says.

Dr. Perugu has undergone specialized training in Palliative Care Education and Practice (PCEP) at Harvard Medical School and Education on Palliative and End-of-life Care (EPEC). She is a member of the American Academy of Pediatrics (AAP) Sections on Bioethics, Section on Perinatal Pediatrics and Hospice and Palliative Care. She has a special interest in quality improvement in palliative care. “Our team is committed to family-centered care and collaborates with every other medical professional taking care of your child,” Dr. Perugu says.


Hoag Memorial Presbyterian Hospital
One Hoag Dr.
Newport Beach, CA 92663

CHOC Children’s Hospital
1201 W. La Veta Ave.
Orange, CA 92868

Administrative Appointments

  • Neonatology, CHOC Children’s Specialists


  • Medical School
    Gandhi Medical College
    Hyderabad, India
  • Residency – Pediatrics
    Department of Pediatrics
    William Beaumont Hospital
    Royal Oak, Michigan
  • Chief Residency – Pediatrics
    Department of Pediatrics
    William Beaumont Hospital
    Royal Oak, Michigan
  • Fellowship – Neonatal-Perinatal Medicine
    Department of Pediatrics
    Division of Neonatology
    Harbor UCLA Medical Center and
    Children’s Hospital of Orange County, California
  • Palliative Care Education and Practice
    Harvard Medical School
    Boston, Massachusetts

Professional Organizations

  • American Academy of Pediatrics
  • American Society of Bioethics and Humanities


  • American Academy of Pediatrics, Bioethics and Palliative Care subcommittees
  • Extracorporeal Life Support Organization
  • American Thoracic Society
  • American Medical Association
  • California Association of Neonatologists

Licensure and Certification

  • Educational Commission for Foreign Medical Graduates
  • Medical Board of California Licensure
  • Neonatal Resuscitation Program Provider
  • Certificate in Business, International Relations and the Political Economy, London School of Economics
  • ECMO Certification, 2009
  • American Board of Pediatrics Certification in General Pediatrics, 2007
  • American Board of Pediatrics Certification in Neonatal – Perinatal Medicine, 2012
  • Education in Palliative and End of Life Care – EPEC Trainer
  • Certificate in Palliative Care Education and Practice, Harvard Medical School

Honors and Awards

  • Orange County Medical Association (OCMA) Physicians of Excellence Honor Roll, 2017, 2018, 2019

Research and Interdisciplinary Team Conferences

  • Unique Model of Neonatal Palliative Care Delivery
    California Association of Neonatologists, Clinical Innovative Program Session, March 2015
  • Unique Model of Neonatal Palliative Care Delivery
    American Academy of Pediatrics: Section of Hospice and Palliative Care, Clinical Innovation Program, Poster Session, October 2015
  • Neonatal Palliative Care Symposium
    Children’s Hospital of Orange County, Orange, CA, 2014, 2015
  • Improving Maternal and Neonatal Outcomes
    March of Dimes, Costa Mesa, California, March 2016
  • Pathophysiology and Prognostication Update for Intraventricular Hemorrhage in Extremely Preterm Infants
    CHOC Children’s Hospital of Orange County, Neonatology Research Meeting, February 2018


Perugu S, Rehan VK, Chow SL, Baylen B Plasma biomarkers and echocardiographic indices of left ventricular function in very low birth weight infants. J Neonatal Perinatal Med 1;7 (3):213-22, 2014.

Perugu S, Holtorf J, Dhar V, Cleary JP: Unique Model of Neonatal Palliative Care Delivery. Pediatrics 02/2016; 137 (Supplement 3):304A-304A.

Perugu S, Cleary JP: Journal of Pediatric Bioethics, 2018 (in print). Referral for Extracorporeal Life Support in Newborns with Hypoxic Ischemic Encephalopathy: A Framework for Integrating Bioethics and Palliative Care Outreach Education

Our neonatologists commonly treat the following conditions in newborns and babies:

  • Sirisha Perugu MD
    • Office: 714-509-4373
    • Specialties: Neonatology, Pediatrics
    • Board Certified: Neonatal-Perinatal Medicine, Pediatrics
    • Additional Languages: Telugu, Hindi
    • On Staff at: CHOC Children's Hospital


Palliative care presentation

Bringing Palliative Care to Your Pediatric Practice

Palliative care in infants and children is a critical and evolving field - Speakers: Dr. Sirisha Perugu, CHOC Children’s neonatologist, and Meg Mohr, FNP-BC, MSN, coordinator of CHOC’s pediatric advanced care team

NICU palliative care

Neonatal Palliative Care Education Symposium

2nd Annual Neonatal Palliative Care Education Symposium recorded on Friday, Oct. 9, 2015 at CHOC Children's Hospital Orange County CA.