All Clinical Trials:

A Phase I/II Study of Pembrolizumab (MK-3475) in Children with advanced melanoma or a PD-L1 positive advanced, relapsed or refractory solid tumor or lymphoma (KEYNOTE-051)

Clinical Trial Protocol # ADVL1621 | Adolescents and Young Adults, Recurrent/Refractory Cancer, Solid Tumors | Contact (714) 509-8646

AALL1521, A Phase 2 Study of the JAK1/JAK2 Inhibitor Ruxolitinib With Chemotherapy in Children With De Novo High-Risk CRLF2-Rearranged and/or JAK PathwayMutant Acute Lymphoblastic Leukemia

Clinical Trial Protocol # AALL1521 | Adolescents and Young Adults, Leukemia | Contact (714) 509-8646

ADVL1513, A Phase 1 Study of Entinostat, an Oral Histone Deacetylase Inhibitor, in Pediatric Patients with Recurrent or Refractory Solid Tumors, including CNS Tumors and Lymphoma

Clinical Trial Protocol # ADVL1513 | Adolescents and Young Adults, Brain Tumor/Central Nervous System/Neuro-Oncology, Recurrent/Refractory Cancer, Solid Tumors | Contact (714) 509-8646

ADVL1615, A Phase 1 Study of Pevonedistat (MLN4924, IND# 136078), a NEDD8 Activating Enzyme (NAE) Inhibitor, in Combination with Temozolomide and Irinotecan in Pediatric Patients with Recurrent or Refractory Solid Tumors

Clinical Trial Protocol # ADVL1615 | Adolescents and Young Adults, Brain Tumor/Central Nervous System/Neuro-Oncology, Recurrent/Refractory Cancer, Solid Tumors | Contact (714) 509-8646

ADVL1722/Eisai E7389G000223: A Phase 2, multicenter, open-label study to assess safety and preliminary activity of eribulin mesylate in pediatric subjects with relapsed/refractory rhabdomyosarcoma (RMS), non-rhabdomyosarcoma soft tissue sarcoma (NRSTS) an

Clinical Trial Protocol # ADVL1722 | Adolescents and Young Adults, Recurrent/Refractory Cancer, Solid Tumors | Contact (714) 509-8646

AHOD1721/BMS CA209744 – Risk-based, response-adapted, Phase II open-label trial of nivolumab + brentuximab vedotin (N + Bv) for children, adolescents, and young adults with relapsed/refractory (R/R) CD30 + classic Hodgkin lymphoma (cHL) after

Clinical Trial Protocol # AHOD1721 | Adolescents and Young Adults, Recurrent/Refractory Cancer, Solid Tumors | Contact (714) 509-8646

Oncology Clinical Trial: A Multi-Center Study Evaluating KTE-C19 in Pediatric and Adolescent Subjects With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia

Clinical Trial | Adolescents and Young Adults, Leukemia/Lymphoma, Recurrent/Refractory Cancer | Contact (714) 509-8646

Oncology Clinical Trial: A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

Clinical Trial Protocol # 10-CBA | Bone Marrow Transplant/Hematopoietic Stem Cell Transplant | Contact (714) 509-8646

Oncology Clinical Trial: A Phase II Study of Dasatinib Therapy in Children and Adolescents with Newly Diagnosed Chronic Phase CML or with Ph+ Leukemias Resistant or Intolerant to Imatinib

Clinical Trial Protocol # 90325 | Adolescents and Young Adults, Leukemia/Lymphoma, Recurrent/Refractory Cancer, oncology | Contact (714) 509-8646

Oncology Clinical Trial: A Phase II, Randomized, Double-blind, Placebo-controlled Study to Examine the Effects of DAS181 in Immunocompromised Subjects With Lower Respiratory Tract Parainfluenza Infection on Supplemental Oxygen

Clinical Trial Protocol # DAS181-2-05 | Supportive Care | Contact (714) 509-8646

Oncology Clinical Trial: A Prospective Study of Remestemcel-L, Ex-vivo Cultured Adult Human Mesenchymal Stromal Cells, for the Treatment of Pediatric Patients Who Have Failed to Respond to Steroid Treatment for Acute GVHD

Clinical Trial Protocol # MSB-GVHD001 | Bone Marrow Transplant/Hematopoietic Stem Cell Transplant, Supportive Care | Contact (714) 509-8646

Oncology Clinical Trial: A Research Sample Repository for Allogeneic Hematopoietic Stem Cell Transplantation

Clinical Trial | Bone Marrow Transplant/Hematopoietic Stem Cell Transplant | Contact (714) 509-8646

Oncology Clinical Trial: A Study of Lenalidomide in Pediatric Subjects With Relapsed or Refractory Acute Myeloid Leukemia

Clinical Trial Protocol # AAML1522 CC-5013-AML-002 | Leukemia/Lymphoma, Recurrent/Refractory Cancer | Contact (714) 509-8646

Oncology Clinical Trial: A Study of Pembrolizumab (MK-3475) in Pediatric Participants With Advanced Melanoma or Advanced, Relapsed, or Refractory PD-L1-Positive Solid Tumors or Lymphoma (MK-3475-051/KEYNOTE-051)

Clinical Trial Protocol # MK3475-051/ADVL1621 | Adolescents and Young Adults, Recurrent/Refractory Cancer, Solid Tumors | Contact (714) 509-8646

Oncology Clinical Trial: A Study of Ramucirumab (LY3009806) in Children With Refractory Solid Tumors

Clinical Trial Protocol # ADVL1416 | Brain Tumor/Central Nervous System/Neuro-Oncology, Recurrent/Refractory Cancer, Solid Tumors | Contact (714) 509-8646

Oncology Clinical Trial: A Study of the Safety and Effectiveness of Apixaban in Preventing Blood Clots in Children With Leukemia Who Have a Central Venous Catheter and Are Treated With PEG L-Asparaginase

Clinical Trial | Leukemia/Lymphoma, Supportive Care | Contact (714) 509-8646

Oncology Clinical Trial: A Study on Drug Monitoring of Asparaginase Activity in Pediatric Patients with Acute Lymphoblastic Leukemia

Clinical Trial | Biology/Genomics, Leukemia/Lymphoma | Contact (714) 509-8646

Oncology Clinical Trial: A Study to Determine Safety, Tolerability and Pharmacokinetics of Oral Dabrafenib In Children and Adolescent Subjects

Clinical Trial | Solid Tumors | Contact (714) 509-8646

Oncology Clinical Trial: An Open Label Study to Examine the Effects of DAS181 Administered by Dry Powder Inhaler (DPI) or Nebulized Formulation in Immunocompromised Subjects With Parainfluenza (PIV) Infection

Clinical Trial Protocol # DAS181-2-06 | Supportive Care | Contact (714) 509-8646

Oncology Clinical Trial: Approaches to the prediction, diagnosis and treatment of cardiac late effects in survivors of childhood cancer.

Clinical Trial | Survivorship | Contact (714) 509-8646

Oncology Clinical Trial: Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma

Clinical Trial Protocol # ANBL00B1 | Biology/Genomics, Solid Tumors | Contact (714) 509-8646

Oncology Clinical Trial: Blinatumomab in Treating Younger Patients With Relapsed B-cell Acute Lymphoblastic Leukemia

Clinical Trial Protocol # AALL1331 | Leukemia/Lymphoma, Recurrent/Refractory Cancer | Contact (714) 509-8646

Oncology Clinical Trial: Blood Sample Markers of Reproductive Hormones in Assessing Ovarian Reserve in Younger Patients With Newly Diagnosed Lymphomas

Clinical Trial Protocol # ALTE11C1 | Adolescents and Young Adults, Fertility, Survivorship | Contact (714) 509-8646

Oncology Clinical Trial: Bortezomib and Sorafenib Tosylate in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia

Clinical Trial Protocol # AAML1031 | Leukemia/Lymphoma | Contact (714) 509-8646

Oncology Clinical Trial: Brentuximab Vedotin and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed Hodgkin Lymphoma

Clinical Trial Protocol # AHOD1331 | Adolescents and Young Adults, Leukemia/Lymphoma | Contact (714) 509-8646

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UC Irvine

CHOC Children's is affiliated with the UC Irvine School of Medicine