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Physician Connection
A Communication Service for Physicians from CHOC and CHOC at Mission. Please Note: Physician Connection is no longer being printed and is now available electronically. Please visit our blog at http://docs.chocchildrens.org for the latest articles for our physician community. You can also receive our electronic Physician Connection newsletter in your inbox by subscribing to our mailing list: http://www.choc.org/subscribe

Research News
CHOC Scientist Investigates Immune Response Of Brain Stem Cells

Henry Klassen, M.D., PhD., a senior scientist in the CHOC neuroscience research lab, co-authored a paper published in the July issue of the peerreviewed journal Stem Cells showing for the first time that stem cells from the central nervous system are not rejected when transplanted. Conducted in conjunction with the Schepens Eye Institute at the Harvard University School of Medicine, this study in mice focused on neuro stem cells transplanted into a site where one might expect rejection. The results may eliminate the need for tissue typing before, and immunosuppressive therapy after, neuro stem cell transplantation for diseases of the eye, spinal cord and brain.

These results hold promise for improving retinal transplant to restore vision for individuals suffering from retinitis pigmentosa, macular degeneration and diabetic retinopathy. The broader implications are the possible restoration of function for those suffering from neuro degenerative diseases like Parkinson's disease.

CHOC Hematology Fellow Amy Lovejoy, M.D., is one of 24 recipients, representing 10 countries from around the world, to receive a research and education grant from the first-ever Bayer Hemophilia Awards program. Initiated in 2002 by Bayer Biological Products, this program is the largest of its kind and provides annual grants totaling $2.75 million to early career investigators, fellows in training and other hemophilia care professionals. Dr. Lovejoy plans to use this grant to study the effects of genetic and molecular changes on clotting Factor XIII expression; clot formation and stability.

Next June, the CHOC Research Institute will sponsor a booth at the national Drug Information Association (DIA) conference in Washington, D.C., showcasing CHOC clinical investigators and the Phase I - IV clinical trials capabilities of the Clinical Research Center. We also hope to have the opportunity to present data from the continuous quality improvement (CQI) model, which is being used to help us meet key performance indicators as established by the pharmaceutical industry for investigative sites. This year, we are focusing on the timeliness of new contract and budget negotiation, and on feasibility assessments to help ensure enrollment targets on new clinical studies are realistically based on available resources and patient population.

For information about open clinical trials at The CHOC Research Institute, please call Contracts and Grants Assistant Carolyn Jones at 714-516-4341.

CHOC CHILDREN'S PUBLICATIONS
PHYSICIAN CONNECTION ENEWSLETTER
KIDS HEALTH MAGAZINE
ANNUAL REPORT
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Children's Hospital of Orange County is affiliated with UC Irvine Healthcare and UC Irvine School of Medicine

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