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Dr. Mary L. Zupanc, Pediatric Neurology

As one of the country’s most highly regarded pediatric epileptologists, Dr. Zupanc has been instrumental in the development of comprehensive pediatric epilepsy programs at Mayo Clinic, Columbia University, and NYU School of Medicine. Dr. Zupanc is highly esteemed for her scholarship and contributions to the advancement of pediatric neurology. She has presented at numerous nationally and internationally recognized lecture series, and is a much sought speaker.

An internationally recognized expert, Dr. Zupanc has published many articles in peer reviewed journals, most notably the Journal of Pediatric Neurology, regarding pediatric epilepsy surgery and outcomes, the efficacy of Felbamate, and infantile spasms. Dr. Zupanc is the author of 15 textbook chapters including the chapter on epilepsy surgery in the field’s primary textbook, Pediatric Neurology.

Dedicated to clinical excellence, Dr. Zupanc is board certified in pediatrics by the American Board of Pediatrics and in child neurology by the American Board of Psychiatry and Neurology. She is board certified in clinical neurophysiology by both the American Board of Psychiatry and Neurology and the American Board of Clinical Neurophysiology. Dr. Zupanc received her medical degree at UCLA, graduating first in her class. She completed pediatric residency at the University of Washington and her pediatric neurology fellowship at the University of Wisconsin. She has had additional training in advanced epilepsy at the University of Wisconsin, UCLA, and Stanford University.

Highly regarded for her expertise, Dr. Zupanc has received numerous awards for teaching recognition and clinical care at each of the major institutions she has served.


CHOC Children’s Hospital
1201 W La Veta
Orange, CA 92868

CHOC Children’s Neuroscience Center
505 S Main St 350
Orange, CA 92868
phone: 888-770-2462
fax: 855-246-2329


  • Child Neurology Fellowship
    University of Wisconsin Hospitals and Clinics, Department of Pediatrics and Neurology, Madison, WI
  • Magnetoencephalography, Surgical Treatment of Epilepsy
    University of California, Los Angeles (UCLA)
  • Neonatal EEG
    Stanford University, California
  • Pediatrics Residency
    Harbor-UCLA Medical Center, Torrance, CA
  • Pediatrics Residency
    University of Washington School of Medicine, Children’s Orthopedic Hospital, Seattle, WA

Academic Appointments

  • American Board of Pediatrics
  • Clinical Professor, Department of Pediatrics, UC Irvine

Administrative Appointments

  • Chair, Neurology, CHOC Children’s
  • Director, Pediatric Comprehensive Epilepsy Program, CHOC Children’s
  • Division Chief, Neurology, CHOC Children’s Specialists

Editorial Boards

  • Current Pediatric Review
  • Family Practice Recertification Journal
  • Pediatric Neurology (Journal)

Professional Organizations

  • American Academy of Neurology
  • American Academy of Pediatrics
  • American Board of Psychiatry and Neurology
  • American Epilepsy Society
  • American Medical Association
  • American Medical Women’s Association
  • Child Neurology Society
  • Epilepsy Foundation of America
  • International Physicians for the Prevention of Nuclear War
  • Physicians for Social Responsibility


Glauser T, Craan A, Shinnar S, et al. Ethosuximide, valproic acid, and lamotrigine in Childhood Absence Epilepsy. N Engl J Med 2010 Mar 4; 362(9):790.

Lew SM, Matthews AE, Mueller WM, Zupanc ML. Forty consecutive hemispherectomies: evolution of technique, outcomes, complications, and lessons learned.  Annual Meeting of the American Society of Pediatric Neurosurgeons, February 2, 2011, J Neurosurg: Ped

Lin JS, Lew SM, Marcuccilli CJ, Mueller WM, Matthews AE, Koop JI, Zupanc ML. Corpus callosotomy in multistage epilepsy surgery in the pediatric population. J Neurosurg Pediatr 2011 Feb; 7(2):189-200.

Wheless, JW, Carmant, L, Bebin, M, Conry, JA, Chiron, C, Elterman, RD, Frost, M, Paolicchi, JM, Shields, W, Thiele, EA, Zupanc, ML, Collins, SD: Magnetic Resonance Imaging Abnormalities Associated with Vigabatrin in Patients with Epilepsy. Epilepsia, 2009; 50(2): 195-205.

Zupanc ML, dos Santos Rubio EJ, Werner R, Schwabe M: Epilepsy Surgery Outcomes – Quality of Life and Seizure Control at Children’s Hospital of Wisconsin. Pediatr Neurol 2010; 42:12-20.

Zupanc ML, Werner RR, Schwabe M. et al. Efficacy of felbamate in the treatment of intractable pediatric epilepsy. Pediatr Neurol 2010; 42:396-403

Zupanc ML. Clinical evaluation and diagnosis of severe epilepsy syndromes of early childhood. J Child Neurol 2009 Aug; 24(8Suppl):6S-14S

Our neurologists commonly treat:

  • Mary L Zupanc MD
    • Appointments:
    • Office: 714-509-7601
    • Specialties: Child Neurology, Clinical Neurophysiology
    • Board Certified: Psychiatry and Neurology with Special Qualification in Child Neurology, Clinical Neurophysiology, Pediatrics, Epilepsy
    • On Staff at: CHOC Children's Hospital and CHOC Children's at Mission Hospital


Dr. Zupanc - Children and Tics

Children and Tics: Dr. Zupanc

In this segment from American Health Journal, Mary Zupanc, MD, provides background on what a tic is and explains the different types of tics.

Dr. Zupanc- Epilepsy

Epilepsy: Dr. Zupanc

Epilepsy is the topic for Mary Zupanc, MD, in this American Health Journal video segment. She explains that epilepsy is two or more unprovoked seizures.

Dr. Zupanc - Children and Headaches

Children and Headaches: Dr. Zupanc

In this segment, Mary Zupanc, MD, speaks about the most common types of headaches. She tells us headaches in children are common & are usually not serious.

Health Topics

Identifying Epilepsy

Identifying Epilepsy

Epilepsy is a seizure disorder characterized by having two or more “unprovoked” seizures. Epilepsy typically begins in infancy or early childhood.



Emerging Trends in Pediatric Epilepsy

Grand Rounds Speaker: Mary Zupanc, MD, Division Chief, Department of Neurology, CHOC Children’s Specialists

Learn more about Dr. Zupanc, Neurology

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UC Irvine

CHOC Children's is affiliated with the UC Irvine School of Medicine