Antonio C Arrieta, M.D.
Office and Contact Information
CHOC Children's Specialists
1201 W La Veta
Orange, CA 92868
phone: (714) 509-8403
fax: (714) 509-4014
map & directions
Physician / Researcher BioAntonio Arrieta, M.D., has worked at CHOC Children’s since 1991 where he is currently director of pediatric infectious diseases and director of infectious disease clinical research. Dr. Arrieta specializes in the treatment of serious community acquired and nosocomial infections and has added expertise in HIV medicine. Dr. Arrieta is board certified in pediatric infectious diseases. He completed his fellowship at UCI-Memorial/Miller Children's Hospital in Long Beach. He did his residency at Southern Illinois University in Springfield. A graduate of Universidad Peruana Cayetano Heredia in Lima, Peru, Dr. Arrieta is fluent in Spanish.
ResearchAs a board certified pediatrician and pediatric infectious disease specialist, Dr. Arrieta is very interested in studying infectious diseases and infections, including pediatric HIV, serious and unusual community-acquired infections, and nosocomial infections. Currently, his main area of research centers on investigating invasive fungal infections and new antifungal agents. He is also investigating immuno response to infections in premature infants.
Dr. Arrieta is constantly publishing poster presentations, articles, and book chapters. He has coauthored more than 50 poster presentations for meetings and conferences including many of the past Interscience Conferences on Antimicrobial Agents and Chemotherapy and Annual Meetings of the European Society for Paediatric Infectious Diseases. His more than 50 articles have been featured in journals including the Pediatric Infectious Disease Journal, the American Journal of Surgery, and the Journal of the American Medical Association. He has written and edited book chapters in the Textbook of Pediatric Infectious Diseases, Pediatric Adolescent Medicine, Pediatric Hospital Medicine, and more.
UCI Memorial/Miller Children's Hospital in Long Beach
Southern Illinois University in Springfield, IL
- Pediatrics and Pediatric Infectious Disease
CHOC Articles & Publications
|Curiosity Drives Infectious Diseases Research
Physician Connection: Summer 2012
A CHOC Children’s investigator-initiated trial into neonates with necrotizing enterocolitis (NEC) has discovered key microbial and survival differences in patients who develop blood stream infect...
|Update: H1N1 Influenza Guidelines
Physician Connection: Fall 2009
In recent months, CHOC Children's infectious diseases specialists have been meeting with community physicians who have concerns about the novel influenza A (H1N1) virus. ...
|In the Spotlight: Antonio Arrieta, M.D.
Physician Connection: Summer 2009
Dr. Arrieta helped develop the CHOC residency program, and continues to participate in the training of residents....
Making a Mark: October 2007
Disorders like cancer, cerebral palsy and diabetes are often in the research spotlight, but other, lesser-known disorders also have a grave impact on children....
|CHOC doc named to FDA appointment
September 09, 2013
Under a recent appointment, a CHOC physician will help the federal government evaluate the safety of drugs used for infectious disease treatment....
|More than 80 CHOC Children's Doctors Named "Physicians of Excellence"
January 03, 2012
More than 80 CHOC Children's physicians, including specialists and pediatricians, are named "Physicians of Excellence" by the Orange County Medical Association....
|More than 60 CHOC Children’s Doctors Named “Physicians of Excellence”
January 04, 2011
More than 60 CHOC Children’s physicians, including specialists and pediatricians, are featured as "Physicians of Excellence" in the January 2011 issue of Orange Coast magazine. The "Physicians of Exc...
|More than 50 CHOC Children's Doctors Named "Physicians of Excellence"
January 04, 2010
The Orange County Medical Association names more than 50 CHOC doctors "Physicians of Excellence."...
Green J, Singh J, Cheung M, Adler F, Ashouri N, Arrieta A. A cluster of pediatric endemic typhus cases in Orange County, California: Caser reports and literature review. Accepted for publication. Pediatric Infectious Disease Journal. August 2010.
Arrieta A, Singh J, Ashouri N, Vargas-Shiraishi O. Streptococcus pneumonie bloodstream infection in hospitalized children after implementation of pneumococcal conjugate vaccine. Submitted to The Journal of Pediatrics. June 2010.
Avery RK, Marty FM, Strasfeld L, Lee I, Arrieta A, Chou S, Tatarowicz W, Villano S. Oral maribavir for treatment of refractory or resistant cytomegalovirus infections in transplant recipients. Transpl Infect Dis. 2010 Dec;12(6):489-96.
Walsh TJ, Driscoll T, Milligan PA, Wood ND, Schlamm H, Groll AH, Jafri H, Arrieta AC, Klein NJ, Lutsar I. Pharmacokinetics, safety, and tolerability of voriconazole in immunocompromised children. Antimicrob Agents Chemother. 2010 Oct;54(10):4116-23.
Chuang M, Singh J, Ashouri N, Katz M, Arrieta A. Listeria Meningitis after Influximab Therapy for Ulcerative Colitis. Journal of Pediaric GI and Nutrition 2010 Mar;50(3): 337-9.
Arrieta AC, Shea K, Dhar V, Cleary JP, Kukreja S, Morris M, Vargas-Shiraishi OM, Ashouri N, Singh J. Once Weekly Liposomal Amphotericin B as Candida Prophylaxis In Very Low Birth Weight Premature Infants; A Prospective, Randomized, Open-Label, Placebo-Controlled Pilot Study. Clinical Therapeutics 2010:32 (2) 265-271
Benjamin DK, Smith PB, Arrieta A, Castro L, Sanchez PJ, Kaufman D, Arnold L, Kovanda L, Sawamoto T, Buell D, Hope W, Walsh TJ. Safety and Pharmacokinetics of Repeat-Dose Micafungin in Young Infants. Clinical Pharmacology & Therapeutics 2010;87 (1) 93-99.
Arrieta, AC, Maddison P, Groll A. Micafungin in Pediatric Patients: Assessment of Safety in Clinical Trials. Accepted for publication. The Pediatric Disease Journal. November 2009.
Smith PB, Walsh TJ, Hope W, Arrieta A, Takada A, Kovanda LL, Kearns GL, Kaufman D, Sawamoto T, Buell DN, Benjamin DK jr. Pharmacokinetics of an Elevated Dosage of Micafungin in Premature Neonates. Pediatr Infect Dis J. 2009 May;28(5):412-5.
Suesaowalak M, Cheung MM, Tucker D, Chang AC, Arrieta A. Chlamydophila pneumoniae Myopericarditis in a Child. Pediatr Cardiol. 2009 Apr;30(3):336-9.
Green JS, Singh J, Ashouri N, Arrieta AC. A Cluster of pediatric Endemic Typhus Cases in Orange County. Case Reports and Literature Review. In progress
Queiroz-Telles F, Berezin E, Leverger G, Freire A, van der Vyver A, Chotpitayasunondh T, Konja J, Diekmann-Berndt H, Koblinger S, Groll A, and Arrieta A. for the Micafungin Invasive Candidiasis Study Group. Micafungin vs Liposomal Amphotericin B for Pediatric Patients with Invasive Candidiasis: A Randomized Double-Blind trial. Pediatr Infect Dis J. 2008 Sep;27(9):820-6
Bendig E, Singh J, Butler TJ, and Arrieta AC. The Impact of the Central Venous Catheter on the Diagnosis of Infective Endocarditis Using Duke Criteria in Children with Staphylococcus aureus bacteremia. Pediatr Infect Dis J 2008;27:636-639
Ashouri N, Singh J, Arrieta A. Micafungin in Pediatrics: when one size does not fit all. Expert Opin. on Drug Metab. & Toxicol. 2008 April; 4 (4): 463-469
Yellin AE, Johnson J, Higareda I, Congeni BL, Arrieta AC, Fernsler D, West J, Gesser R. Ertapenem or ticarcillin/clavulanate for the treatment of intra-abdominal infections or acute pelvic infections in pediatric patients. Am J Surg. 2007 Sep; 194 (3):367-74.
Hope WW, Seibel NK, Schwartz CL, Arrieta A, Flynn P, Shad A, Albano E, Keirns JJ. Buell DN, Gumbo T, Drusano GL, Walsh TJ. Population Pharmacokinetics of Micafungin in Pediatric Patients and the Implications for Antifungal Dosing. Antimicrob Agents Chemother. 2007 Jul;51:3714-9. Anaisse EJ, Segal BH, Graybill JR, Arndt C, Perfect JR, Kleinberg M, Pappas P, Benjamin D, Rubin R, Aberg JA, Adderson EE, Adler FC, Akan H, Akova M, Almyroudis NG, Alexander BD, Andes D, Arrieta A, et al. Clinical Research in the lay press: irresponsible journalism raises a huge dose of doubt. Clin Infect Dis. 2006 Oct 15;43 (8): 1031-9.
Arrieta A. Treatment of Invasive Fungal Infections in the Pediatric Patient with Echinocandin therapy. Submitted and accepted for publication- Infectious Diseases Express Report
Seibel NL, Schwartz C, Arrieta A, Flynn P, Shad A, Albano E, Keirns J, Lau WM, Facklam DP, Buell DP, Walsh TJ. Safety, Tolerability and Pharmacokinetics of Micafungin (FK-463) in Febrile Neutropenic Patients. Antimicrobial Agents Chemother. 2005. Aug; 49 (8): 3317-24.
Berk DR, Falkovitz-Halpern MS, Hill DW, Albin C, Arrieta A, Bork JM, Cohan D, Nilson B, Petru A, Ruiz J, Weintrub PS, Wenman W, Maldonado YA; California Pediatric HIV Study Group. Temporal trends in early clinical manifestations of perinatal HIV infection in a population based cohort. JAMA. 2005 May 11; 293-(18) 2221-31.
Singh J, Arrieta AC. Management of Meningococcemia: an updated review. Indian J Pediatr. 2004 Oct; 71 (10): 909-13.
Armenian SH, Singh J, Arrieta AC. Risk Factors for mortality resulting from blood stream infections in a pediatric intensive care unit. Pediatr Infect Dis J. 2005 Apr; 24 (4): 309-14.
Walsh TJ, Karlsson MO, Driscoll T, Arguedas AG, Adamson P, Saez-Llorens X, Vora AJ, Arrieta AC, Blumer J, Lutsar I, Milligan P, Wood N. Pharmacokinetics and safety of intravenous voriconazole in children after single or multiple dose administration. Antimicrob Agents Chemother. 2004. Jun; 48(6):2166-72
Carter RW, Singh J, Archambault C, Arrieta A. Severe lactic acidosis in association with Reverse transcriptase inhibitors with potential response to L-carnitine in a pediatric HIV positive patient. AIDS Care STDS. 2004. Mar: 10 (3): 131-4.
Arrieta A, Singh J. Management of Recurrent and Persistent Acute Otitis Media: New options with familiar antibiotics. Pediatr Infect Dis J. 2004 Feb; 23 (2 Suppl): S115-24.
Block SL, Arrieta A, Seibel M, McLinn S, Eppes SC, Murphy MJ. Single dose (30 mg/kg) Azithromycin compared with 10 day Amoxicillin/clavulanate (45 mg/kg/per day) for the treatment of Uncomplicated Acute Otitis Media. Current Therapeutic Research. Supplement A. Vol 64, number 8 Sep 2003.
Singh J, Arrieta AC, Lang DJ. A Neonate with Chronic Meningitis and Hydrocephalus. Pediatr Infect Dis J. 2003. Nov; 22(11): 1025-6, 1030-1.
Arrieta A, Arguedas A, Fernandez P, Block SL, Emperanza P, Vargas SL, Erhart WA, de Caprariis PJ, Rothermel CD. High-Dose Azithromycin vs High-Dose Amoxicillin/Clavulanate for Treatment of Children with Recurrent or Persistent Acute Otitis Media. Antimicrob Agents Chemother. 2003 Oct; 47 (10): 3179-86.
Dunne MW, Khurana C, Mohs AA, Rodriguez A, Arrieta A, McLinn S, Krogstad JA, Blatter M, Schwartz R, Vargas SL, Emparanza, P, Fernandez P, Gooch WM, Aspin M, Podgore J, Roine I, Blumer JL, Ehrlich GD, Chow J. Efficacy of Single-Dose Azithromycin in Treatment of Acute Otitis Media in Children after a Baseline Tympanocentesis. Antimicrob Agents Chemother. 2003 Aug; 47(8): 2663-5.
Scharer G, Zaldivar F, Gonzalez G, Vargas-Shiraishi O, Singh J, Arrieta A. Systemic Inflammatory Response in Children with Acute Otitis Media due to Streptococcus pneumoniae and the impact of treatment with Clarithromycin. Clin Diagn Lab Immunol. 2003. Jul; 10(4): 721-4.
Ashouri N, Butler J, Vargas-Shiraishi OM, Singh J, Arrieta AC. Urinary Tract Infection in Neonates: How aggressive a Workup and Therapy? Infections in Medicine. 2003. Feb; 20(2): 98-102.
Saez-Llorens X, McCoig C, Feris JM, Vargas SL, Klugman KP; Hussey GD, Krencj RW, Falleiros-Carvalho LH, Arguedas AG, Bradley J, Arrieta AC, Wald ER, Pancorbo S, McCracken GH Jr, Marques SR; and the Trovan Meningitis Study Group. Quinolone treatment for pediatric bacterial meningitis: a comparative study of trovafloxacin and ceftriaxone with or without vancomycin. Pediatr Infect Dis J. 2002. Jan: 21 (1); 14-22.
Singh J, Burr B, Stringham D, and Arrieta AC Commonly used Antibacterial and Antifungal agents for Hospitalised Paediatric Patients: Implications for Therapy with Emphasis on Clinical Pharmacokinetics. Paediatr Drugs 2001; 3 (10) 733-761.
Kassir KK, Vargas-Shiraishi OM, Zaldivar F, Berman M, J Singh and Arrieta AC. Cytokine Profiles in Pediatric Patients Treated with Antibiotics for Pyelonephritis: Potential Therapeutic Impact. Clin Diagn Lab Immunol. 2001 Nov; 8 (6): 1060-3.
Singh J, Arrieta AC, Lang DL, and Ahuja, G. Tuberculous Parotitis in an Infant Infections in Medicine, April 2001. Vol 18 (4). 217-20.
Arrieta AC and Bradley J. The Empiric Use of Cefepime in the Treatment of Serious Urinary Tract Infections in Children. Pediatr Infect Dis J. 2001 Mar; 20(3):350-5.
Bradley J, Arrieta AC .The Empiric Use of Cefepime in the Treatment of Lower Respiratory Tract Infections in Children. Pediatr Infect Dis J. 2001 Mar; 20(3): 343-9.
Bradley J, Behrendt C, Arrieta AC, Harrison C, Loeffler A, Iaconis J, Wald E. Convalescent-Phase Outpatient Parenteral Anti-infective Therapy for Children with Complicated Appendicitis. Pediatr Infect Dis J. 2001 Jan; 20(1): 19-24.
Wingard JR, White MH, Anaissie EJ, Rafalli JT, Goodman JL, Arrieta AC and the AmBisome/Abelcet Study Group. A Randomized Double Blind Comparative Safety Trial of AmBisome and Abelcet in Febrile Neutropenic Patients. Clin Infect Dis. 2000 Nov; 31(5)1155-63.
Singh J, and Arrieta AC. Of Bugs and Drugs: A Practical Guide through the Labyrinth of Antimicrobial Therapy for Respiratory Tract Infections. Postgrad Med. 1999 Nov; 106: (6) 47-54.
Snedden S, Rudoy R, Arrieta AC, Blumer J and the Meropenem Pediatric Infection Group. Meropenem versus Cefotaxime-Based Therapy for the Initial Treatment of Infants and Children Hospitalized with Non-CNS Infections. Clin Drug Invest, 1999;Jan; 17(1): 9-20.
Singh, J and Arrieta AC. New Cephalosporins. Seminars in Pediatric Infectious Diseases, 1999; 10 (1): 14-22.
The IMpact-RSV Study Group. Palivizumab, a Humanized Respiratory Syncytial Virus Monoclonal Antibody, Reduces Hospitalization From Respiratory Syncytial Virus Infection in High-risk Infants. Pediatrics, Sept 1998; 102 (3); 531-536.
Arrieta AC. Use of Meropenem in the treatment of pediatric infections. Clinl Infect Dis, 1997; 24 (Suppl 2): S207-12.
Vugia DC, Peterson CL, Meyers HB, Kim KS, Arrieta AC, Schlievert PM, Kaplan EL, Werner SB, and Mascola L. Invasive group A streptococcal infections in children with varicella in Southern California. Pediatr Infect Dis J 1996 15:146-50.
Aspin MM, Hoberman A, McCarty J, McLinn S, Aronf S, Lang DJ, and Arrieta AC. A comparative study of the safety and efficacy of clarithromycin and amoxicillin/clavulanate in the treatment of acute otitis media in children. J Pediatr.1994 Jul; 125: (1) 136-41.
Arrieta AC, Marks MI, Franchi, LM, Maggi JC, Muchnick C. Endobronchial tuberculosis presenting as respiratory failure in an infant. Clin Pediatr (Phila). 1993 Dec; 32(12):747-9.
Arrieta AC, Anas N. Cholera, hemolytic uremic syndrome and the press. California Pediatrician pp 64-66, Fall 1992.
Arrieta AC, Zaleska M, Stutman HR, Marks MI. Vitamin A levels in children with measles in Long Beach, California. J Pediatr 1992 Jul; 121(1):75-8.
Arrieta AC, Akaniro JC, Stutman HR, Vargas OM, Marks MI. In vitro activity of teicoplanin compared to vancomycin against methicillin resistant Staphylococcus aureus derived from clinical isolates and cystic fibrosis sputum. Diagn Microbiol Infect Dis. 1992 Mar-Apr; 15(3): 247-51.
Arguedas AG, Arrieta AC, Stutman HR, Akaniro JC, Marks MI. In vitro activity of cefprozil (BMY 28100) and loracarbef (LY 163892) against pathogens obtained from middle ear fluid. J Antimicrob Chemother 1991 Mar; 27: (3) 311-8.
Arrieta AC, Stutman HR. Coxsackie B2 meningitis with unusually high white blood cell count in cerebrospinal fluid. Pediatr Infect Dis J. 1991 Mar; 10(3): 250-1.
Stutman HR Arrieta AC. Detection of anti-BCG secreting cells in cerebrospinal fluid. Lancet 1990 Aug 25; 336(8713):514.