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Antonio C Arrieta, M.D.

Dr. Arrieta has staff privileges at CHOC Orange & CHOC Mission

Orange, CA
Mission Viejo, CA
Orange, CA

Infectious Disease

Research Focus:
Pediatric HIV, serious and unusual community-acquired infections, nosocomial infections.


Published Works:

Office and Contact Information

CHOC Children's Specialists
1201 W La Veta
Orange, CA 92868
phone: (714) 509-8403
fax: (714) 509-4014
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CHOC Children's at Mission Hospital
27700 Medical Center Rd
Mission Viejo, CA 92691
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St Joseph Hospital
1100 W Stewart Dr
Orange, CA 92868
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Web Site:

Administrative Appointments

  • President-Elect, Medical Staff, CHOC Children's
  • Division Chief, Infectious Disease, CHOC Children's Specialists

Academic Appointments

  • Clinical Professor, Pediatrics, UC Irvine

Physician / Researcher Bio

As a nationally-recognized expert in pediatric infectious disease, Dr. Arrieta specializes in the treatment of serious community acquired and nosocomial infections and has added expertise in HIV medicine. His main area of research centers on investigating invasive fungal infections and new antifungal agents. He is also investigating immuno response to infections in premature infants.

A prolific author, Dr. Arrieta is has written many poster presentations, articles, and book chapters. He has coauthored more than 50 poster presentations for meetings and conferences including many of the past Interscience Conferences on Antimicrobial Agents and Chemotherapy and Annual Meetings of the European Society for Paediatric Infectious Diseases. His more than 50 articles have been featured in journals including the Pediatric Infectious Disease Journal, the American Journal of Surgery, and the Journal of the American Medical Association. He has written and edited book chapters in the Textbook of Pediatric Infectious Diseases, Pediatric Adolescent Medicine and Pediatric Hospital Medicine, among others.

Dedicated to clinical excellence, Dr Arrieta is board certified in pediatrics and pediatric infectious diseases. Prior to joining CHOC Children’s, Dr. Arrieta attended medical school at Universidad Peruana Cayetano Heredia in Lima, Peru. He completed his residency at Southern Illinois University and conducted his fellowship traingin in pediatric infectious diseases at Millers Children in Long Beach and University of California, Irvine.

Recognized for his leadership and expertise, Dr. Arrieta is consistently voted as one of Orange County’s “Top Doctors” by the Orange County Medical Association. Dr. Arrieta speaks fluent in Spanish.


  • Fellowship
    UCI Memorial/Miller Children's Hospital in Long Beach
  • Residency
    Southern Illinois University in Springfield, IL

Board Certifications

  • Pediatric Infectious Disease
    American Board of Pediatrics

Honors and Awards

  • Physician of Excellence
    OCMA, Multiple years

Editorial Boards

  • Journal of Pediatric Infectious Disease
  • The Pediatric Infectious Disease Journal.
  • Pediatrics Journal
  • Clinical Infectious Disease Journal

CHOC Articles & Publications

Curiosity Drives Infectious Diseases Research
Physician Connection: Summer 2012
A CHOC Children’s investigator-initiated trial into neonates with necrotizing enterocolitis (NEC) has discovered key microbial and survival differences in patients who develop blood stream infect...
Update: H1N1 Influenza Guidelines
Physician Connection: Fall 2009
In recent months, CHOC Children's infectious diseases specialists have been meeting with community physicians who have concerns about the novel influenza A (H1N1) virus. ...
In the Spotlight: Antonio Arrieta, M.D.
Physician Connection: Summer 2009
Dr. Arrieta helped develop the CHOC residency program, and continues to participate in the training of residents....
Research Spotlight:
Making a Mark: October 2007
Disorders like cancer, cerebral palsy and diabetes are often in the research spotlight, but other, lesser-known disorders also have a grave impact on children....


CHOC doc named to FDA appointment
September 09, 2013
Under a recent appointment, a CHOC physician will help the federal government evaluate the safety of drugs used for infectious disease treatment....
More than 80 CHOC Children's Doctors Named "Physicians of Excellence"
January 03, 2012
More than 80 CHOC Children's physicians, including specialists and pediatricians, are named "Physicians of Excellence" by the Orange County Medical Association....
More than 60 CHOC Children’s Doctors Named “Physicians of Excellence”
January 04, 2011
More than 60 CHOC Children’s physicians, including specialists and pediatricians, are featured as "Physicians of Excellence" in the January 2011 issue of Orange Coast magazine. The "Physicians of Exc...
More than 50 CHOC Children's Doctors Named "Physicians of Excellence"
January 04, 2010
The Orange County Medical Association names more than 50 CHOC doctors "Physicians of Excellence."...

Published Works

Sampson M, Bloom B, Capparelli E, Benjamin D, Arrieta A, et al. Intestinal Fatty-Acid Binding Protein and Metronidazole Response in Premature Infants. Submitted to Neonatology. May 2013

Chin, DM, Singh J, Holmes WN, Arrieta AC. Back mass in a 13 year-old boy. Pediatr Infect Dis J 2013 April;32(4): 422-23

Benjamin D, Deville J, Azie N, Kovanda L, Roy M, Wu C, Arrieta A. Safety and Pharmacokinetic Profiles of repeated-Dose Micafungin in Children and Adolescents Treated for Invasive Candidiasis. Submitted to The Pediatric Infectious Diseases Journal. January 2013.

Cohen-Wolkowiez M, Castro L, Pointdexter B, Bidegain M, Arrieta A, Schelonka R, Ward M, Wade K, et al. “Safety and Efficacy of Meropenem in Infants with Suspected or Complicated Intra-abdominal Infections”. Clin Infect Dis. 2012 Dec;55(11):1495-1502. Epub 2012 Sep 5.

Albano E, Azie N, Roy M, Townsend R, Arrieta C. Pharmacokinetic and Safety Profiles of Repeated-Dose Prophylactic Micafungin in Children and Adolescents Undergoing Hematopoietic Stem Cell Transplantation. Submitted to Clinical Pharmacology and Therapeutics. November 2012.

Undre N, Stevenson P, Freire A, Arrieta A. Optimization of Micafungin Dosing Regimen in Children.. Pediatr Infect Dis J. 2012 Nov;31(11):1212.

Steinbech W, Roilides E, Berman D, Hoffman J, Groll A, Bin-Hussain I, Castagnola E, Arrieta A, Knapp K, Walsh T, Zaoutis T, et al. Results from a Prospective, International, Epidemiologic Study of Invasive Candidiasis in Children and Neonates. Pediatr Infect Dis J. 2012 ;31:1252-1257.

Freire A, Arrieta A, Stevenson P, Undre N. Pharmacolinetics of Micafungin in Pediatric Patients with Invasive Candidiasis and Candidemia. Pediatr Infect Dis J.2012 Jun;31(6):630-2

Nieves D, Arrieta A, Singh J, Adler F, Ashouri N, McGuire T. Clinical and Laboratory Features of Pertussis in Infants at the Onset of a California Epidemic. Pediatr. 2011 Dec;159(6):1044-6. Epub 2011 Sep 16

Driscoll T, Yu L, Haydar F, Krance R, Nemecek E, Blumer J, Arrieta A, et al. Pharmacokinetics and safety of intravenous voriconazole to oral switch in immunocompromised children compared to adults. Antimicrob. Agents Chemother. 2011 Dec;55(12):5770-9

Benjamin D, Arrieta A, Smith, Brian, Cohen-Wolkowiez M, Castro L. et al. Population Pharmacokinetics of Meropenem in Plasma and Cerebrospinal Fluid of Infants with Suspected or Complicated Intra-abdominal Infections. Pediatr Infect Dis J. 2011 Oct;30(10):844-9

Arrieta A, Maddison P, Groll, A. Safety of Micafungin in Pediatric Clinical Trials. Pediatr Infect Dis J. 2011 Jun;30(6):e97-e102

Green J, Singh J, Cheung M, Adler F, Ashouri N, Arrieta A. A cluster of pediatric endemic typhus cases in Orange County, California: Case reports and literature review. Pediatr Infect Dis J. 2011 Feb:30(2):163-5

Arrieta A, Singh J, Ashouri N, Vargas-Shiraishi O. Streptococcus pneumonie bloodstream infection in hospitalized children after implementation of pneumococcal conjugate vaccine. J Pediatr Infect Dis 2011;6(2)

Walsh Tj, Drisctoll T, Milligan PA, Wood, Arrieta A. Pharmacokinetics, Safety, and Tolerability of Voriconazole in Immunocompromised Children. Antimicrob Agents Chemother. 2010 Oct;54(10):4116-23.

Hope WW. Smith PB, Arrieta A, Buell DN, Roy M, et al. Population pharmacokinetics of micafungin in neonates and young infants. Antimicrob Agents Chemother.2010 Jun;54(6):2633-7

Chuang M, Singh J, Ashouri N, Katz M, Arrieta A. Listeria Meningitis after Influximab Therapy for Ulcerative Colitis. Journal of Pediaric GI and Nutrition 2010 Mar;50(3): 337-9.

Antonio C Arrieta MD, Kathy Shea BA, Vijay Dhar MD, John Cleary MD, Sudeep Kukreja MD, Mindy Morris RNP, Ofelia Vargas-Shiraishi MS, Negar Ashouri MD, Jasjit Singh MD. Once Weekly Liposomal Amphotericin B as Candida Prophylaxis In Very Low Birth Weight Premature Infants; A Prospective, Randomized, Open-Label, Placebo-Controlled Pilot Study. Clinical Therapeutics 2010:32 (2) 265-271

Benjamin DK, Smith PB, Arrieta A, Castro L, Sanchez PJ, Kaufman D, Arnold L, Kovanda L, Sawamoto T, Buell D, Hope W, Walsh TJ. Safety and Pharmacokinetics of Repeat-Dose Micafungin in Young Infants. Clinical Pharmacology & Therapeutics 2010;87 (1) 93-99.

Smith PB, Walsh TJ, Hope W, Arrieta A, Takada A, Kovanda LL, Kearns GL, Kaufman D, Sawamoto T, Buell DN, Benjamin DK jr. Pharmacokinetics of an Elevated Dosage of Micafungin in Premature Neonates. Pediatr Infect Dis J. 2009 May;28(5):412-5.

Suesaowalak M, Cheung MM, Tucker D, Chang AC, Arrieta A. Chlamydophila pneumoniae Myopericarditis in a Child. Pediatr Cardiol. 2009 Apr;30(3):336-9.

Lectures and Presentations

  • "Overlapping seasonality of paraneumonic empyema and bacteremia due to Pneumococcus in Southern California Children, does influenza matter?"
  • "Population Pharmacolinetics (PK) of Oral and Intravenously Adminsitred Tedizolid Phosphate in Adolescent Patients."
  • "Safety of Micafungin in Infants less than 90 days of age."
  • "Micafungin Safety in Pediatric Patients in Clinical Practice."
  • "Bacteremic Urinary Tract Infection Compared to Primary Bacteremia in Children < 3 months. Is Pyelonephritis a Serious Bacterial Infection?"
  • "A Phase 1 open-label, multicentre, single-dose, pharmacokinetic, safety and tolerance study of oral tedizolid phosphate in 12 to 17 year old patients."
  • "Outcome of late onset neonatal sepsis due to bacteremic urinary tract infections."
  • "Central line associated blood stream infections in pediatric patients with short bowel syndrome."
  • "Clinical and Laboratory Features of Pertussis During a California Epidemic."
  • "Impact of intra-abdominal pathology in late onset blood stream infections in neonatal intensive care patients."
  • "Pharmacokinetics and Safety of Meropenem in Young Infants with Intra-Abdominal Infections."
  • "Staphylococcus aureus (S aureus) Bacteremia in Hospitalized Infants Less Than Three Months of Age."
  • "Oral Maribavir (MBV) for Treatment of Resistant or Refractory Cytomegalovirus (CMV) Infections in Transplant Recipients."
  • "Identification of Factors Affecting Incidence and Outcome of Candidemia in a Neonatal Intensive Care Unit for Developing Prophylaxis Strategies."
  • "Clinical and Microbiological Factors Affecting Outcome in Hospitalized Children with Candidemia."
  • "Streptococcus Pneumoiae Blood Stream Infections (BSI) in Hospitalized Children after Broad Utilization of Heptavalente Pneumococcal Conjugate Vaccine (PCV-7)."
  • "Micafungin: Overview of Safety in Children."
  • "Micafungin: Overview of Efficacy in Children."
  • "Micafungin for the Treatment of Pediatric Invasive Fungal Infections."
  • "Safety and Pharmacokinetics of Repeat-Dose Micafungin in Neonates and Young Infants."


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chocChildren's Hospital of Orange County | UCI University of California, Irvine

Children's Hospital of Orange County is affiliated with UC Irvine Healthcare and UC Irvine School of Medicine

CHOC Children's - 1201 W La Veta Ave, Orange, CA. Phone: 714-997-3000. .