CHOC Children's Physician Detail - Steven M Neudorf, MD

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Steven M Neudorf, MD

Dr. Neudorf has staff privileges at CHOC & CHOC at Mission

Location:
Orange, CA

Specialty:
Hematology-Oncology, Pediatric

Research Focus:
Blood and marrow transplants, pediatric leukemia

Published Works:

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Office and Contact Information

CHOC Children's Specialists
1201 W La Veta
Orange, CA 92868
phone: (714) 509-8636
fax: (714) 509-4748
map & directions

Web Site:
http://www.choc.org/specialists

Physician / Researcher Bio

Clinical Director of the CHOC Blood and Marrow Transplant Program, Steven Neudorf, M.D. has specialized expertise in stem-cell transplantation. He is board certified in pediatrics and pediatric hematology/oncology. Dr. Neudorf served his fellowship, residency and internship through the University of Minnesota. He received his medical training at University of Health Sciences/Chicago Medical School, in Illinois. Dr. Neudorf is a member of the CHOC Children's Specialists Board of Directors.

Research

Dr. Neudorf is dedicated to his patients and research in blood and marrow transplants and pediatric leukemia. Moreover, he has published more than 50 papers, abstracts, and other publications related to blood and marrow transplants and leukemia. He is currently working with his associates at CHOC and UCI to improve outcomes following transfusions and to discover new agents and therapies for acute leukemia.

Education

Fellowship
Pediatric Immunology/Bone Marrow Transplant at University of Minnesota
Pediatric Residency
University of Minnesota
Medical School
Chicago Medical School, Chicago, IL

Board Certifications

Pediatric Hematology/Oncology, Hematology, Pediatrics

More than 60 CHOC Children’s Doctors Named “Physicians of Excellence”
January 04, 2011
More than 60 CHOC Children’s physicians, including specialists and pediatricians, are featured as "Physicians of Excellence" in the January 2011 issue of Orange Coast magazine. The "Physicians of Exc...

CHOC Children's Joins Excell Pivotal Study For Leukemia And Lymphoma Patients As Only Pediatric Site On West Coast
February 11, 2009
CHOC Children's is the only pediatric site for the ExCell study on the West Coast. The pivotal registration study is testing the safety and efficacy of StemEx, a potential alternative transplantation ...

Published Works

Kline RM, Neudorf SM, Baron HI. Correction of Celiac Disease After Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myelogenous Leukemia. Pediatrics 2007;120;e1120 – e1122.

Neudorf, S., Sanders, J., Kobrinsky, N. Alonzo, T.A., Buxton, A.B., Buckley, J.D. Howells, W., Gold, S., Barnard, D.R., DeSwarte, J. Kalousek, D., Lange, B.J. and Woods, W.G. Autologous bone marrow transplantation (ABMT) for children with AML in first remission. Bone Marrow Transplant. 2007 Aug;40(4):313-8. Epub 2007 Jun 11.

Alonzo TA, Wells RJ, Woods WG, Lange B, Gerbing RB, Buxton AB, Neudorf S, Sanders J, Smith FO, Feig SA. Postremission therapy for children with acute myeloid leukemia: the children's cancer group experience in the transplant era. Leukemia. 2005 Jun;19(6):965-70. Review.

Hakumei Oh, Fausto R. Loberiza Jr, Mei-Jie Zhang, Olle Ringdén, Hideki Akiyama, Takayoshi Asai, Shuichi Miyawaki, Shinichiro Okamoto, Mary M. Horowitz, Joseph H. Antin, Asad Bashey, Jennifer M. Bird, Matthew H. Carabasi, Joseph W. Fay, Robert Peter Gale, Roger H. Giller, John M. Goldman, Gregory A. Hale, Richard E. Harris, Jean Henslee-Downey, Hans-Jochem Kolb, Mark R. Litzow, Philip L. McCarthy, Steven M. Neudorf, Derek S. Serna, Gerard Sociè, Pierre Tiberghien, and A. John Barett. Comparison of graft-versus-host-disease and survival after HLA-identical sibling bone marrow transplantation in ethnic populations, BLOOD.2005;105:1408-1416.

Neudorf, S., Nourani, A., Kempert, P., Shen, V., Sender, L., Kirov, I. Chemotherapy and donor leukocyte infusions for relapsed juvenile myelomonocytic leukemia (JMML). Bone Marrow Transplantation 33 , 1069, 2004

Neudorf, S., Sanders, J., Kobrinsky, N. Alonzo, T.A., Buxton, A.B., Buckley, J.D. Howells, W., Gold, S., Barnard, D.R., DeSwarte, J. Kalousek, D., Lange, B.J. and Woods, W.G. Allogeneic bone marrow transplantation (BMT) for children with AML in first remission demonstrates a role for graft versus leukemia in the maintenance of disease free survival. Blood 103; 3655 - 61, 2004

Barnard DR, Lange B, Alonzo TA, Buckley J, Kobrinsky N, Gold S, Neudorf S, Sanders J, Burden L, Woods WG. Acute myeloid leukemia and myelodysplastic syndrome in children previously treated for cancer: comparison with primary presentation. Blood 100: 427-34, 2002.

Woods, W., Barnard, D., Alonzo, T.A., Buckley, J., Kobrinsky, N., Arthur, D., Sanders, J., Neudorf, S. Gold, S., Lange, B. A prospective study of 90 children treated for juvenile myelo-monocytic leukemia or myelodysplastic syndrome: A report from the Children’s Cancer Group. J. Clin. Oncol. 20: 434-440, 2002.

Woods, W. Neudorf, S., Gold,S., Sanders, J. Buckley, J. Barnard, D., Dusenberry, K., DeSwarte, J., Arthur, D., Lange, B., Kobrinsky, N. A comparison of allogeneic bone marrow transplantation, autologous bone marrow transplantation, and aggressive chemotherapy in children with AML in remission: A report from the Children’s Cancer group. Blood, 97 (1): 97: 56-62, 2001.

Lones M.A., Kirov I., Said J.W., Shintaku I.P., Neudorf S. Post-transplant lymphoproliferative disorder after autologous peripheral stem cell transplantation in a pediatric patient. Bone Marrow Transplantation. 26 (9) 1021-24, 2000.

Ball ED, Wilson J, Phelps V, Neudorf S. Autologous bone marrow transplantation for acute myeloid leukemia in remission or first relapse using monoclonal antibody-purged marrow: results of phase II studies with long-term follow-up. Bone Marrow Transplantation. 25 (8): 823-29, 2000.

Levine JE, Wiley J, Kletzel M, Yanik G, Hutchinson RJ, Koehler M, Neudorf S, Cytokine-mobilized allogeneic peripheral blood stem cell transplant in children result in rapid engraftment and high incidence of chronic GVHD. Bone Marrow Transplantation 25 (1): 13-18, 2000.

Davies S, Ramsay N, Klein J, Weisdorf D, Bolwell B, Cahn JY, Camitta B, Gale R, Giralt S, Heilmann C, Henslee-Downey J, Herzig R, Hutchinson R, Keating A, Lazarus H, Milone G, Neudorf S, Powles R, Prentice H, Schiller G, Socie G, Vowels M, Wiley J, Yeager A, Horowitz M. Comparison of preparative regimens in transplants for children with acute lymphoblastic leukemia. J. Clin. Oncol. 18 (2): 340-47, 2000.

Woods WG. Sanders JE. Neudorf S. Treatment of acute myeloid leukemia [Letter] N. Engl. J. Med. 340 (18):1437-9, 1999

Lange B, Kobrinsky N, Barnard D, Arthur D, Buckley J, Howells W, Gold S, Sanders J, Neudorf S, Smith F, Woods W.: Distinctive demography, biology and outcome of acute myeloid leukemia and myelodysplastic syndrome in children with Down Syndrome: Children’s Cancer Group Studies 2861 and 2891. Blood 91: 608-615, 1998.

Akman, I., Ostrov, B., Neudorf S. Autoimmune manifestations of Wiskott Aldrich syndrome. Seminars in Arthritis and Rheumatism. 27: 218-225, 1998.

Rushton JJ, Zorich GP, Stolc V, Neudorf SML: Characterization of a promoter within the first intron of the human CD4 gene. Eur. J. Biochem. 245: 768-773, 1997.

Neudorf S, Rybka W, Ball E, Blatt J, Bloom E, Corey S, DeMagalhaes-Silverman M, Koehler M, Lister J, Mierski J, Mirrro J, Pincus S, Wilson J, Wollman M, Donnenberg AD: The use of centrifugal elutriation for the depletion of T cells from unrelated donor bone marrow. J. Hematotherapy 6: 351-359, 1997.

Koehler M, St. George K, Ehrlich GD, Mirro J, Neudorf S, Rinaldo C: Prevention of CMV disease in allogeneic BMT recipients by CMV antigenemia-guided preemptive therapy. J. Ped. Hem. Onc. 19: 43-47, 1997.

Barnard DR, Kalousek D, Wiersma SR, Lange BJ, Benjamin DR, Arthur DC, Buckley JD, Kobrinsky N, Neudorf S, Sanders J, Miller LP, DeSwarte J, Shina DC, Hammond D, Woods WG: Morphologic, immunologic and myelodysplastic syndrome in childhood: A report from the Children’s Cancer Group. Leukemia 10: 5-12, 1996.

Woods WG, Kobrinsky N, Buckley J, Lee JW, Sanders J, Neudorf S, Gold S, Barnard D, DeSwarte J, Dusenberry K, Kalousek D, Arthur D, Lange BJ: Timed-sequential induction therapy improves post-remission outcome in acute myeloid leukemia irrespective of the use of bone marrow transplantation: A report from the Children’s Cancer Group. Blood 87: 4979-89, 1996.

Neudorf SML, Blatt J, Corey S, Koehler M. Wollman M, Rosner G, Rybka W: Graft failure following an umbilical cord blood transplant in a patient with severe aplastic anemia (letter). Blood 85: 24991, 1995.

Koehler M, Neudorf S, Howrie D, Mirro J, Blatt J, Corey S, Wollman M, Kelly-Ekeroth V, Reyes J: FK506 (tacrolimus) in the treatment of steroid resistant acute graft vs host disease in children undergoing bone marrow transplantation. Bone Marrow Transplantation 15 (6): 895-899, 1995.

Woods WG., Kobrinsky N, Buckley J, Neudorf S, Sanders J, Miller L, Barnard D, Benjamin D, DeSwarte J, Kalousek D, Shina D, Hammond GD, Lange BJ: Intensively timed induction therapy followed by autologous or allogeneic bone marrow transplantation for children with acute myeloid leukemia or myelodysplastic syndrome: A Children’s Cancer Group Pilot Study. J. Clin. Oncol. 11 (8): 1448-1457, 1993.

Monafo WJ, Polmar SH, Neudorf S, Mather A, Filipovich AH: A hereditary immunodeficiency characterized by CD8+ T-lymphocyte deficiency and impaired lymphocyte activation. Clin. Exp. Immunol. 90: 390-393, 1992.

Neudorf S, Jones M, Parker S, Papes R, Lattier D: Phorbol esters down regulate transcription and translation of the CD4 gene. J. Immunol. 146: 2836-40, 1991.

McConville B, Strecichen-Asch P, Harris R, Neudorf S, Sambrano J, Lampkin B, Baly D, Frederick B, Hoffman C, Woodman D: Pediatric bone marrow transplants: Psychological aspects. Can. J. Psychiatry 35 (9): 769-75, 1990.

Lucas P, Shearer G, Neudorf S, Gress R: The human anti-murine xenogeneic cytotoxic response: I. Dependence on responder antigen presenting cells. J. Immunol. 144: 4548-54, 1990.

Neudorf S, Jones J, McCarthy B, Harmony J, Choi E: The CD4 molecule transmits biochemical information important in the regulation of T lymphocyte activity. Cell. Immunol. 125: 301-14, 1990.

DeLaat C, Files B, Harris R, Neudorf S, Lampkin B: Undifferentiated acute leukemia and lineage infidelity (difficulties in classification and management). Med. Ped. Oncol. 18: 15-21, 1990.

Neudorf S, Delaat C, Jones M: Expression of CD4 on acute non-lymphocytic leukemia (ANLL) cell lines. J. Clin. Lab. Anal. 3: 312-15, 1989.

Neudorf S, Hendrixson M, Hammond J, Harris R, Hake D, Jones M, Pietryga D, Sambrano J: A modified method for human bone marrow filtration prior to bone marrow transplantation. Bone Marrow Transplantation 4: 97-101, 1989.

Neudorf S, Jones M: The effects of anti-thymocyte globulin (ATG) on natural killer (NK) cell activity. Exp. Hematol. 16: 831-835, 1988.

Woolfrey AE, Neudorf S, Filipovich AH. Comparison of two immunomechanical methods of T-cell depletion of human bone marrow for prevention of graft vs host disease: Soybean lectin agglutination and sheep erythrocyte rosette depletion vs triple rosette depletion. Thymus 7: 327-34, 1985.

Neudorf S, Kersey J, Filipovich A: Lymphoid progenitor cells in severe combined immunodeficiency. J. Clin. Immunol. 5: 26-30, 1885.

Goldes J, Filipovich A, Neudorf S, Bender M, Ostrow R, Faras A, Goltz R: Epidermodysplasia verruciformis in a setting of common variable immunodeficiency. Ped. Derm. 2: 136-9, 1984.

Neudorf S, LeBien T, Bollum F, Kersey J: Double fluorochrome analysis of human bone marrow lymphoid cells using terminal transferase and anti-T cell monoclonal antibodies. Exp. Hematol. 12: 69-74, 1984

Neudorf S, LeBien T, Kersey J: Characterization of thymocytes expressing the common acute lymphoblastic leukemia antigen. Leukemia Res. 8: 173-179, 1984.

Neudorf S, Filipovich A, Kersey J: The Use of Monoclonal Antibodies in Bone Marrow Transplantation. Prog. Clin. Biol. Res. 149: 367-378, 1984.

Neudorf S, Khan MAQ: Pick up and metabolism of DDT, dieldrin and photodieldrin by a fresh water algae (Ankistrodesmus Amallodides) and a microcrustacean (Daphnia Pulex). Bull. Environ. Contam. Tox. 13: 443, 1975.

Khan HM, Neudorf S, Khan MAQ: Absorption and elimination of photodieldrin by Daphnia and goldfish. Bull. Environ. Contam. Tox. 13: 582, 1975.

Review and Chapters
Bradfield, SM., Neudorf, S., Rubin, E., Sandler, ES., Prevention and Treatment of Infectious Disease. Pediatric Hematopoietic Stem Cell Transplantation. Edited by Ronald M. Kline. 2006: informa Healthcare USA, Inc., New York, pp 27 – 63.

Kirov, I., Neudorf, S. Biology and clinical utility of hematopoietic stem cells. Pediatric pathology and molecular medicine. 19 (4) 283-302, 2000.

Neudorf S, Filipovich, A. Bone marrow transplantation for congenital immunodeficiencies. In: Ball, Lister, Law (eds.) Hematopoietic stem cell therapy Churchill Livingstone, NY, p.154-167 2000.

Neudorf S. Bone marrow transplantation, In: Burg, Polin, Ingelfinger, Wald, eds. Current Pediatric Therapy 16. W.B. Saunders, Ed.

Neudorf S. Bone marrow transplantation for Gaucher disease. In: Barranger (ed), Gaucher disease: Clinical perspectives. Gardiner-Caldwell Vol. 5 (2) Sept., 1997.

Koehler M, Mirro J, Neudorf S. Surgical problems associated with bone marrow transplantation. In: Pediatric Surgery, 5th Edition, Rowe MI (ed): Mosby-Year Book, Inc., 1995.

Gronert B, Neudorf S. Anesthesia for bone marrow transplants. In: Cook and Davis (eds), Anesthetic Principles for Organ Transplantation. Raven Press, NY, p. 229-40, 1995

Neudorf S, Sambrano J, Pietryga D. Immunologic principles and techniques of bone marrow transplantation. In: Pochedley (ed), Neoplastic Diseases of Childhood, p. 291-309, 1995.

Neudorf S, Sambrano J, Pietryga D. Bone marrow transplantation for correction of primary immunodeficiencies. In: Pochedly and Johnson (eds), Bone Marrow Transplantation in Children. Raven Press, NY, p.165-80 1990.

Harris R, Neudorf S, McGill M. CMV-seronegative blood products for prevention of cytomegaloviral pneumonia in CMV-seronegative marrow transplant recipients – A study of 50 patients. In: Gale, Champlin (eds), Progress in Bone Marrow Transplantation. UCLA Symposia on Molecular and Cellular Biology, New Series, Volume 53. Alan R Liss, Inc., New York, NY, pp 577-581, 1987.

Blazar BR, Whitley CB, Desnick RJ, Pierpont ME, Filipovich AH, Ramsay NKC, Kersey JH, Orr HT, Yasmineh WG, Tsai MY, Vitek CR, McGovern MM, Neudorf S, Krivit W. Comparison of enzymatic activity with evidence of engraftment in patient with inborn errors of metabolism following allogeneic bone marrow transplantation. March of Dimes Original Article Series 22: 135-152, 1986.

Neudorf S, Filipovich A, Ramsay N, Kersey J. Prevention and treatment of acute graft vs host disease. Semin. Hematol. 21: 91-100, 1984.

Neudorf S, Filipovich A, Kersey J. The use of monoclonal antibodies in bone marrow transplantation. Prog. Clin. Biol. Res. 149: 367-378, 1984.

Neudorf S, Filipovich A, Kersey J. Immunoreconstitution by bone marrow transplantation decreases lymphoproliferative malignancies and severe combined immune deficiency syndromes. In: Purtilo D, ed, Immune Deficiency and Cancer: Epstein-Barr Virus and Lymphoproliferative Malignancies. Plenum Press, New York, pp 471-480, 1984.

Neudorf S, Filipovich A, Kersey J. Recent advances in bone marrow transplantation. In: R Weiner, C Schiffer, E Hackel (eds), Bone Marrow Transplantation. American Association of Blood Banks, Washington, DC, pp 147-160, 1983.