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Mary L Zupanc, MD

Dr. Zupanc has staff privileges at CHOC Orange & CHOC Mission

Orange, CA
Orange, CA

Child Neurology
Clinical Neurophysiology

Published Works:

Office and Contact Information

CHOC Children's Neurology Center
1120 W La Veta Avenue
Suite 125
Orange, CA 92868
phone: (714) 509-7601
fax: (855) 246-2329
arrow map & directions

CHOC Children's Specialists
1201 W La Veta
Orange, CA 92868
phone: (714) 509-7601
fax: (855) 246-2329
arrow map & directions

Web Site:

Administrative Appointments

  • Chair, Neurology, CHOC Children's
  • Director, Pediatric Comprehensive Epilepsy Program, CHOC Children's
  • Division Chief, Neurology, CHOC Children's Specialists

Academic Appointments

  • Clinical Professor, Department of Pediatrics, UC Irvine

Physician Bio

As one of the country’s most highly regarded pediatric epileptologists, Dr. Zupanc has been instrumental in the development of comprehensive pediatric epilepsy programs at Mayo Clinic, Columbia University, and NYU School of Medicine. Dr. Zupanc is highly esteemed for her scholarship and contributions to the advancement of pediatric neurology. She has presented at numerous nationally and internationally recognized lecture series, and is a much sought speaker.

A internationally recognized expert, Dr. Zupanc has published many articles in peer reviewed journals, most notably the “Journal of Pediatric Neurology,” regarding pediatric epilepsy surgery and outcomes, the efficacy of Felbamate, and infantile spasms. Dr. Zupanc is the author of 15 textbook chapters including the chapter on epilepsy surgery in the field’s primary textbook, “Pediatric Neurology.”

Dedicated to clinical excellence, Dr. Zupanc is board certified in pediatrics by the American Board of Pediatrics and in child neurology by the American Board of Psychiatry and Neurology. She is board certified in clinical neurophysiology by both the American Board of Psychiatry and Neurology and the American Board of Clinical Neurophysiology. Dr. Zupanc received her medical degree at UCLA, graduating first in her class. She completed pediatric residency at the University of Washington and her pediatric neurology fellowship at the University of Wisconsin. She has had additional training in advanced epilepsy at the University of Wisconsin, UCLA, and Stanford University.

Highly regarded for her expertise, Dr. Zupanc has received numerous awards for teaching recognition and clinical care at each of the major institutions she has served.


  • Pediatrics Residency
    University of Washington School of Medicine, Children's Orthopedic Hospital, Seattle, WA
  • Pediatrics Residency
    Harbor-UCLA Medical Center, Torrance, CA
  • Child Neurology Fellowship
    University of Wisconsin Hospitals and Clinics, Department of Pediatrics and Neurology, Madison, WI
  • Neonatal EEG
    Stanford University, California
  • Magnetoencephalography, Surgical Treatment of Epilepsy
    University of California, Los Angeles (UCLA)

Board Certifications

  • Pediatrics
  • Neurology with Special Qualifications in Child Neurology
  • Clinical Neurophysiology
  • Epilepsy

Professional Organizations

  • Epilepsy Foundation of America
  • American Medical Women's Association
  • American Medical Association
  • American Academy of Pediatrics
  • American Academy of Neurology
  • American Board of Psychiatry and Neurology
  • Child Neurology Society
  • American Epilepsy Society
  • Physicians for Social Responsibility
  • International Physicians for the Prevention of Nuclear War

Editorial Boards

  • Pediatric Neurology (Journal)
  • Family Practice Recertification Journal
  • Current Pediatric Review


Dr. Zupanc, CHOC Children's - Epilepsy Dr. Zupanc, CHOC Children's - Epilepsy
In this segment from American Health Journal, Mary Zupanc, MD, explains the condition of epilepsy. ...
Dr. Zupanc, CHOC Children's - Children and Headaches Dr. Zupanc, CHOC Children's - Children and Headaches
In this segment from American Health Journal, Mary Zupanc, MD, speaks about the most common types of headaches children will have. ...
Dr. Zupanc, CHOC Children's - Children and Tics Dr. Zupanc, CHOC Children's - Children and Tics
In this segment from American Health Journal, Mary Zupanc, MD, provides background on what a tic is and explains the different types of tics. ...

CHOC Articles & Publications

Calming the Epileptic Storm
CHOC Children's Annual Report: FY 2011
The activity in a child’s brain during a seizure is often likened to an electrical storm....
Quieting the Epileptic Storm
Kid's Health (Archive): Fall 2011
When children with epilepsy have a seizure, it can be compared to an electrical storm raging in their brain....
Nationally Recognized Pediatric Epileptologist
Physician Connection: Summer 2011
In February, a nationally recognized pediatric epileptologist who built comprehensive pediatric epilepsy programs at Mayo Clinic, Columbia University and the NYU School of Medicine became director...


CHOC Children’s Comprehensive Epilepsy Program Earns National Recognition as Level 4 Center
April 09, 2012
The CHOC Children’s Comprehensive Epilepsy Program recently achieved recognition by the National Association of Epilepsy Centers (NAEC) as a Level 4 epilepsy center....


Madison and her family are proud to be part of the CHOC family. ...
Dr. Zupanc
Dr. Mary Zupanc is the medical director of the CHOC Children’s Comprehensive Epilepsy Program and chief of the division of neurology. ...

Published Works

Wheless, JW, Carmant, L, Bebin, M, Conry, JA, Chiron, C, Elterman, RD, Frost, M, Paolicchi, JM, Shields, W, Thiele, EA, Zupanc, ML, Collins, SD: Magnetic Resonance Imaging Abnormalities Associated with Vigabatrin in Patients with Epilepsy. Epilepsia, 2009; 50(2): 195-205.

Zupanc ML. Clinical evaluation and diagnosis of severe epilepsy syndromes of early childhood. J Child Neurol 2009 Aug; 24(8Suppl):6S-14S

Zupanc ML, dos Santos Rubio EJ, Werner R, Schwabe M: Epilepsy Surgery Outcomes – Quality of Life and Seizure Control at Children’s Hospital of Wisconsin. Pediatr Neurol 2010; 42:12-20.

Zupanc ML, Werner RR, Schwabe M. et al. Efficacy of felbamate in the treatment of intractable pediatric epilepsy. Pediatr Neurol 2010; 42:396-403

Glauser T, Craan A, Shinnar S, et al. Ethosuximide, valproic acid, and lamotrigine in Childhood Absence Epilepsy. N Engl J Med 2010 Mar 4; 362(9):790.

Lin JS, Lew SM, Marcuccilli CJ, Mueller WM, Matthews AE, Koop JI, Zupanc ML. Corpus callosotomy in multistage epilepsy surgery in the pediatric population. J Neurosurg Pediatr 2011 Feb; 7(2):189-200.

Lew SM, Matthews AE, Mueller WM, Zupanc ML. “Forty consecutive hemispherectomies: evolution of technique, outcomes, complications, and lessons learned.” Annual Meeting of the American Society of Pediatric Neurosurgeons, February 2, 2011, J Neurosurg: Ped


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Children's Hospital of Orange County is affiliated with UC Irvine Healthcare and UC Irvine School of Medicine

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