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Anthony C Chang, MD

Dr. Chang has staff privileges at CHOC Orange & CHOC Mission

Orange, CA
Orange, Ca
Mission Viejo, CA


Published Works:

Office and Contact Information

CHOC Children's Specialists
505 S. Main Street
Suite 200
Orange, CA 92868
phone: 714-509-3939
fax: 714-509-3949
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Children's Hospital of Orange County
1201 W. La Veta Ave.
Orange, Ca 92868-3874
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CHOC Children's at Mission Hospital
27700 Medical Center Rd
Mission Viejo, CA 92691
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Web Site:

Administrative Appointments

  • Medical Director, Heart Institute, CHOC Chlidren's
  • Director, Pediatric Cardiac Intensive Care Service, CHOC Children's
  • Division Chief, Cardiology, CHOC Children's Specialists

Physician / Researcher Bio

Internationally-recognized as an expert in the field of pediatric cardiology, Dr. Chang leads pediatric heart teams all over the world. He was one of the founding members of the Asia-Pacific Pediatric Cardiac Society (APPCS) and will be initiating the foundation arm of the society at the bequest of the board. Dr. Chang has been voted “Physician of Excellence” by the Orange County Medical Association and also selected as one of America’s “Top Doctors,” “Top Pediatricians,” and “Best Cardiologists” by several organizations.

A world-renown leader in pediatric cardiology innovation, Dr. Chang is a member of the grant review committee for pediatric research at the National Institutes of Health. Respected in his field, he is a member the board of directors for the American Heart Association. Providing leadership in education, he has served with the faculty of UCLA School of Public Health (eMPH program) and has taught global health for UCLA’s eMPH. He also teaches pediatric cardiology to cardiology fellows and holds a volunteer faculty appointment at the UCLA School of Medicine..

A prolific author, Dr. Chang is the chief editor of the textbook “Pediatric Cardiac Intensive Care” and the past president-elect of the Pediatric Cardiac Intensive Care Society (PCICS). He is the chief editor of the textbook “Heart Failure in Children and Young Adults.” He is an associate editor of “Pediatric Critical Care Medicine” and is on the editorial board of cardiology in the “Young and Congenital Heart Today.” He is a regular reviewer for “Circulation,” “Pediatric Critical Care Medicine,” “Critical Care Medicine,” and numerous other journals. He publishes and lectures widely on topics of pediatric cardiac intensive care, heart failure, sudden cardiac death, adult congenital heart disease, and other aspects of congenital heart disease. He has served as program director for numerous large international conferences and symposia.

With more that 20 years of experience, Dr. Chang’s responsibilities have included serving as a staff cardiologist at Boston Children’s Hospital with a position in the cardiac intensive care unit where he was later promoted to assistant professor at Harvard School of Medicine. He was later the medical director of the cardiac intensive care programs at Children’s Hospital of Los Angeles and Miami Children’s Hospital. He is also formerly the medical director of pediatric cardiac intensive care service and chief of critical care cardiology at Texas Children’s Hospital and a tenured associate professor at Baylor College of Medicine.

Dedicated to clinical excellence, Dr. Chang is board certified in pediatric cardiology. Prior to joining CHOC Children’s, Dr. Chang attended medical school at Georgetown University Medical School in Washington, D.C. He completed his residency training in pediatrics at Children’'s Hospital National Medical Center in Washington, D.C. and served his fellowship in cardiology at Children’s Hospital of Philadelphia. Dr. Chang has a master’s degree in healthcare administration from University of Miami School of Business, from which he graduated with the McGaw Prize for academic excellence. He has a master’s degree in public health from UCLA, from which he graduated with the Dean’s Award for academic excellence. He is enrolled in the master’s in biomedical informatics (MS-BMI) program at Stanford University.


  • Graduate Education - M.S. (Biomedical Informatics) (in progress)
    Stanford University, Stanford, California
  • Graduate Education - M.P.H.
    University of California at Los Angeles School of Public Health, Los Angeles, California
  • Graduate Education - M.B.A (Healthcare Administration)
    University of Miami School of Business, Miami, Florida
  • Pediatric Cardiology Fellowship
    Children's Hospital of Philadelphia, Pennsylvania
  • Pediatric Residency
    Children's Hospital National Medical Center, Washington, DC
  • Medical School
    Georgetown University Medical School, Washington, DC

Board Certifications

  • Pediatric Cardiology
    American Board of Pediatrics

Honors and Awards

  • Dean’s Outstanding Scholarship Award (graduated first in class) and Delta Omega (Public Health Honor Society)
    UCLA MPH Program and School of Public Health
  • Outstanding Teaching Award
    UCLA Pediatric Cardiology Program

Professional Organizations

  • American Medical Association
  • American College of Cardiology
  • American Heart Association (Executive Vice President, Miami Chapter)
  • Society of Critical Care Medicine (scientific consultant)
  • Pediatric Cardiac Intensive Care Society (president-elect)
  • American College of Physician Executives (advanced standing)
  • American College of Healthcare Executives
  • American College of Medical Practice Management
  • American Society of Artificial Internal Organs


Why Come to CHOC Why Come to CHOC
CHOC physicians, patients and their families talk about how CHOC provides expert pediatric care. Includes stories from our Heart, Neuroscience, Cancer and Critical Care programs. ...
Dr. Chang - CHOC Children's Heart Institute - LEAPS Dr. Chang - CHOC Children's Heart Institute - LEAPS
Dr. Anthony Chang, Medical Director of the CHOC Childrens Heart Institute discusses Life-threatening Events Associated with Pediatric Patients in Sports (LEAPS) and the increase of sudden cardiac deat ...
Dr. Chang - Stimulants and the Effects on the Heart Dr. Chang - Stimulants and the Effects on the Heart
In this segment from American Health Journal, Dr. Anthony Chang, CHOC Children's, explains what it means when a medication indicates there is a stimulant inside. ...
My Favorite Thing About Being a Doctor: Dr. Chang My Favorite Thing About Being a Doctor: Dr. Chang
Dr. Anthony Chang explains what it's like to see his small patients grow up to be adults. ...
Artificial Intelligence and Nanotechnology: Dr. Chang, CHOC Children's Artificial Intelligence and Nanotechnology: Dr. Chang, CHOC Children's
Dr. Anthony Chang, Medical Director of the CHOC Childrens Heart Institute, shares about the amount of medical knowledge that is available now and how it's doubling in 3-5 years. Join us for the Pediat ...
Genomic Medicine, Robotic Surgery and Regenerative Medicine: Dr. Chang, CHOC Children's Genomic Medicine, Robotic Surgery and Regenerative Medicine: Dr. Chang, CHOC Children's
Dr. Anthony Chang, Medical Director of the CHOC Childrens Heart Institute, tells us that a babie's DNA can be sequenced in less that 50 hours. Join us for the Pediatrics 2040: Trends and Innovations f ...
Medical Devices and and the Future of Medicine: Dr. Chang, CHOC Children's Medical Devices and and the Future of Medicine: Dr. Chang, CHOC Children's
Dr. Anthony Chang, Medical Director of the CHOC Childrens Heart Institute, informs us about new medical devices and applications and why the next 25 years of medicine is so exciting. Join us for the P ...
More Media...

Blog Articles

CHOC Docs Blog Articles

CHOC Articles & Publications

Leonardo and the Da Vinci Pediatric and Congenital Heart Project: The Genesis and Mentoring of a SuperComputer with a “Living” Multi-Dimensional Artificial Intelligence Architecture
CHOC Articles: March 2012
Paper by Anthony C. Chang, MD, MBA, MPH that discusses artificial intelligence solutions for congenital heart disease...
“ACE” is the Rx for Sudden Cardiac Death
Physician Connection: Summer 2010
“Orange County has the highest per-capita of National Collegiate Athletic Association (NCAA) and Olympic athletes in the nation. It certainly behooves us to protect our athletes by providing adequate ...
CHOC Children's Institutes
CHOC Children's Annual Report: FY 2010
The CHOC Children’s Institutes: Heart, Orthopaedic, and Cancer...
CHOC Scientist Exploring Light's Possibilities For Children
Physician Connection: Summer 2008
A biomedical scientist at CHOC is collaborating with several physicians to explore medical applications of light to provide non invasive diagnoses. ...
CHOC's New Era In Pediatric Cardiac Care
Physician Connection: Winter 2008
It was a day to remember our hospital's history, celebrate the advances in pediatric and cardiac intensive care, and learn more from the experts who continually push the boundaries of possibility. A n...
CHOC Heart Program Positioned To Become Regional Powerhouse
Physician Connection: Fall 2006
Earlier this year, CHOC welcomed Anthony C. Chang, M.D., as the new medical director of The CHOC Heart Institute....
Meet Dr. Chang
Physician Connection: Fall 2006
Medical Director, The CHOC Heart Institute...
Five Year Old Girl Survives Congenital Heart Condition and Fatal Lung Disease
Making a Mark: October 2006
When Erica Ortega was 3 days old, she was diagnosed with hypoplastic left heart syndrome, a congenital heart condition that if left untreated is usually fatal. Since then, the 5-year-old has undergone...
Creating a World-Class Heart Institute at CHOC
Making a Mark: October 2006
The Orange County community may already know about the excellence in cardiac care delivered at CHOC?the only facility in the region specializing in the diagnosis and treatment of pediatric car...
More Articles...


CHOC Children's-hosted conference explores future of pediatric medicine
September 10, 2013
An upcoming conference hosted by CHOC Children’s will explore emerging trends and future innovations in pediatric health care with an aim to stimulate and challenge attendees’ approach to care now and...
More than 80 CHOC Children's Doctors Named "Physicians of Excellence"
January 03, 2012
More than 80 CHOC Children's physicians, including specialists and pediatricians, are named "Physicians of Excellence" by the Orange County Medical Association....
More than 60 CHOC Children’s Doctors Named “Physicians of Excellence”
January 04, 2011
More than 60 CHOC Children’s physicians, including specialists and pediatricians, are featured as "Physicians of Excellence" in the January 2011 issue of Orange Coast magazine. The "Physicians of Exc...
More than 50 CHOC Children's Doctors Named "Physicians of Excellence"
January 04, 2010
The Orange County Medical Association names more than 50 CHOC doctors "Physicians of Excellence."...


Dr. Chang
Renowned specialist leads the CHOC Heart Institute with the Japanese philosophy of kaizen. ...

Published Works

Stapleton GE, Eble BK, Dickerson HA, Andropoulos DB, and Chang AC.
Mesenteric oxygen desaturation in an infant with congenital heart disease and necrotizing enterocolotis.
Texas Heart Institute Jounal 2007; 34:442-4.

Rossano JW, Smith EO, Fraser Jr. CD, McKenzie ED, Chang AC, Hemingway A,Price JF, Dickerson HA, and Mott AR.
Adults undergoing cardiac surgery at a children’s hospital: an analysis of perioperative morbidity.
Annual of Thoracic Surgery 2007; 83:606-12.

Tan LH, Jefferies JL, Liang JF, Denfield SW, Dreyer WJ, Mott AR, Grenier MA, Dickerson HA, Price JF, Towbin JA, Ou CN, and Chang AC.
Concentrations of brain natriuretic peptide in the plasma predicts outcomes of treatment of children with decompensated heart failure admitted to the Intensive Care unit.
Cardiology in the Young 2007; 17:397-406.

Tan LH, and Chang AC
Transhepatic approach as an alternative long-term central venous access in critically ill children with complex congenital heart disease: a new angle to an old problem?
Pediatric Critical Care Medicine 2007; 8:298-9.

Tan LH, Hess B, Diaz LK, Cassady CI, Xu AM, Di Chiara L, Fraser CD, Andropoulos D, Chang AC, and Seidel FG.
Survey of the use of peripherally inserted central venous catheters in neonates with critical congenital cardiac disease.
Cardiology in the Young 2007; 17:196-201

Suominen PK, STayer S, Wang W, and Chang AC.
The effect of temperature correction of blood gas values on the accuracy of end-tidal carbon dioxide monitoring in children after cardiac surgery.
American Society for Artificial Internal Organs Journal 2007; 53:670-4.

Kuzin JK, Yborra JG, Taylor MD, Chang AC, Altman CA, Whitney GM, and Mott AR.
Family-member presence during interventions in the intensive care unit: Perceptions of pediatric cardiac intensive care providers.
Pediatrics 2007; 120:895-901.

Jeffries JL, Price JF, Denfield SW, Chang AC, Dreyer WJ, McMahon CJ, Grenier MA, Clunie SK, Thomas A, Moffett BS, Wann TS, Smith EO, and Towbin JA.
Safety and efficacy of nesiritide in pediatric heart failure.
Journal of Cardiac Failure 2007; 13:541-8.

Breinholt JP, fraser CD, Dreyer WJ, Chang AC, O’Brian Smith E, Heinle JS, Mckenzie E, Clunie SK, Towbin JA, and Denfield SW.
The efficacy of mitral valve surgery in children with dilated cardiomyopathy and severe mitral regurgitation.
Pediatric Cardiology 2008; 29:13-8.

Price JF, Mott AR, Dickerson HA, Jefferies JL, Nelson DP, Chang AC, O’ Brian Smith E, Towbin JA, Dreyer WJ, Denfield SW, and Goldstein SL.
Worsening renal function in children hospitalized with decompensated heart failure: evidence for a pediatric cardiorenal syndrome?
Pediatric Critical Care Medicine 2008; 9:279-84.

Falkensammer CB, Heinle JS, and Chang AC.
Serial plasma BNP levels in assessing inadequate left ventricular decompression on ECMO.
Pediatric Cardiology 2008; 29-808-11.

Johnson, BA, and Chang AC.
Near-infrared spectroscopy and tissue oxygenation: the unremitting quest for the holy grail.
Pediatric Critical Care Medicine 2008; 9:123-4.

McCanta AC, Chang AC, and Weiner K.
Cardiomyopathy in a child with neutropenia and motor delay.
Current Opinion Pediatrics 2008; 20:605-7.

LaRovere JM, Jeffries HE, Sachdeva RC, Rice TB, Wetzel RC, Cooper DS, Bird GL, Ghanayem NS, Checchia PA, Chang AC, and Wessel DL.
Databases for assessing the outcomes of the treatment of patients with congenital and paediatric cardiac disease-the perspective of critical care.
Cardiology in the Young 2008; Suppl 2:130-6.

Li SC, Wang L, Jiang H, Acevedo J, Chang AC, and Loudon WG.
Stem cell engineering for treatment of heart diseases: potentials and challenges.
Cell Biology International 2009; 35:120-3.

Suesaowalak M, Cheung MM, Tucker D, Chang AC, Chu J, and Arrieta A.
Chlamydophila pneumoniae myopericarditis in a child.
Pediatric Cardiology 2009; 30:336-9.

Magliola R, Moreno G, Vassallo JC, Landry LM, Althabe M, Balestrini M, Charroqui A, Salgado G, Lataza E, and Chang AC.
Levosimendan, a new inotropic drug: experience in children with acute heart failure
Archivos Argentines de Pediatria 2009; 107:139-45

Chang AC, and Macrae D.
Neonates with congenital cardiac defects and pulmonary hypertension.
Cardiology in the Young 2009; Suppl 1:4-7.

Suesaowalak M. Cleary JP, and Chang AC.
Advances in diagnosis and treatment of pulmonary arterial hypertensionin neonates and children with congenital heart disease.
World Journal of Pediatrics 2010; 6:13-31.

Bronicki RA, Herrera M, Mink R, Domico M, Tucker D, Chang AC, and Anas G.
Hemodynamics and cerebral oxygenation following repair of Tetralogy of Fallot: the effects of converting from positive pressure ventilation to spontaneous breathing.
Congenital Heart disease Journal 2010; 5:416-21.

Bronicki RA, and Chang AC.
Management of postoperative pediatric cardiac surgical patient.
Critical Care Medicine 2011; 39:1974-84.

Chang AC.
Quality and safety in the pediatric cardiac intensive care unit: it is time to leave the pit stop and the cockpit and perfect the handover.
Pediatric Critical Care Medicine 2011; 12:361-2.

Li SC, Acevedo J, Schwartz PH, Wang L, Jiang H, Luo J, Pestell RG, Loudon WG, and Chang AC.
Mechanisms for Progenitor Cell-mediated Repair for Ischemic Heart Injury.
Current Stem Cell Research Therapy 2010.

Lee GJ, Cohen R, Chang AC, Cleary JP.
Angiotensin Converting Enzyme Inhibitor (ACEI) – Induced Acute Renal Failure in Premature Newborns with Congenital Heart Disease.
Journal of Pediatric Phamacology and Therapeutics 2010 Oct;15(4):290-6.

Tan LH, Du LZ, Carr MR, Kuzin JK, Moffett BS, and Chang AC.
Captopril induced reversible acute renal failure in a premature neonate with double outlet right ventricle and congestive heart failure.
World Journal of Pediatrics 2011; 7:89-91.

Chang AC.
Primary prevention of sudden cardiac death of the young athlete: the controversy about the screening electrocardiogram and its innovative artificial intelligence solution.
Pediatric Cardiology 2012; 33:428-33.

Chang AC.
Determination of cardiac output in critically ill children: are we any closer to the ideal methodology?
Pediatric Critical Care Medical 2012; 13:99.

Chang AC, Morell J, Rebolledo M.
Ten Innovative Concepts for the Pediatric Cardiology Clinical Service.
Congenital Cardiology Today, May 2012.

Chang AC, Musen M.
Artificial Intelligence in Pediatric Cardiology: An Innovative Transformation In Patient Care, Clinical Research, and Medical Education.
Congenital Cardiology Today, November 2012.


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Children's Hospital of Orange County is affiliated with UC Irvine Healthcare and UC Irvine School of Medicine

CHOC Children's - 1201 W La Veta Ave, Orange, CA. Phone: 714-997-3000. .